Elsevier

Genomics

Volume 13, Issue 2, June 1992, Pages 469-471
Genomics

Short communication
Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs

https://doi.org/10.1016/0888-7543(92)90275-WGet rights and content

Abstract

We have cloned full-length DDC cDNAs from a human hepatoma cDNA library [DDC; dopa decarboxylase; aromatic-L-amino acid decarboxylase, EC 4.1.1.28]. The protein encoded by hepatoma cells is the same as that encoded by adrenal chromaffin derived pheochromocytoma cells, despite reported differences in biochemical properties. We have confirmed the location of the DDC gene to chromosome 7 using a new panel of somatic cell hybrids, and we have localized the gene to band p11 on chromosome 7 by fluorescent in situ hybridization. The human gene retains 65% amino acid identity with Drosophila DDC (Accession No. X04426) and considerable structural similarity with other enzymes (F.R. Jackson, 1990, J. Mol. Evol. 31: 325–329, and references therein).

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Present address: Department of Biology, California Institute of Technology, Pasadena, CA.

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