Elsevier

Genomics

Volume 11, Issue 3, November 1991, Pages 709-719
Genomics

A map of 22 loci on human chromosome 22

https://doi.org/10.1016/0888-7543(91)90079-TGet rights and content

Abstract

We constructed a genetic linkage map of the entire long arm of human chromosome 22 with 30 polymorphic markers, defining 22 loci. The map consists of a continuous linkage group 110 cM long, when male and female recombination fractions are combined; average distance between the loci is 5.2 cM. All loci were placed on the map with high support against alternative orders (odds in excess of 1000:1). The order of loci presented in our map is in full agreement with that of the previous linkage maps of chromosome 22 and with the physical assignment of markers. Two markers included in this map, KI-831 (D22S212) and pEFZ31 (D22S32), allowed us to better define the region of the (11;22) translocation breakpoint specific for Ewing sarcoma. Ten additional polymorphic markers were placed on the 22-loci map with odds lower than 1000:1 against alternative locations. In total, we have introduced 29 new markers on the linkage map of chromosome 22.

References (51)

  • H. Zankl et al.

    Correlations between clinical and cytogenetical data in 180 human meningiomas

    Cancer Genet. Cytogenet

    (1980)
  • F.R. Zhang et al.

    Mapping of human chromosome 22 by in situ hybridization

    Genomics

    (1990)
  • F.R. Zhang et al.

    The neuroepithelioma breakpoint on chromosome 22 is proximal to the meningioma locus

    Genomics

    (1990)
  • A. Aurias et al.

    Chromosomal translocations in Ewing's sarcoma

    N. Engl. J. Med

    (1983)
  • G. Bell et al.

    Polymorphic DNA region adjacent to the 5′ end of the human insulin gene

  • M. Budarf et al.

    Human differentiation stimulating factor (leukemia inhibitory factor, human interleukin DA) gene maps distal to the Ewing sarcoma breakpoint on 22q

    Cytogenet. Cell Genet

    (1989)
  • M. Budarf et al.

    Comparative mapping of the constitutional and tumor-associated 11;22 translocations

    Am. J. Hum. Genet

    (1989)
  • E. Carlbom et al.

    Identification of twelve new RFLP-markers on chromosome 22q11-qter

    Hum. Genet

    (1991)
  • W. Cavenee et al.

    Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13

    Am. J. Hum. Genet

    (1984)
  • J.P. De Chadarevian et al.

    Reciprocal translocation in small-cell sarcomas

    N. Engl. J. Med

    (1984)
  • J.P. Dumanski et al.

    Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma

  • J.P. Dumanski

    Rapid procedures for the isolation of random chromosome-specific DNA probes from a phage library

    Technique

    (1990)
  • J.P. Dumanski et al.

    Isolation of anonymous polymorphic DNA fragments from human chromosome 22q12-qter

    Hum. Genet

    (1990)
  • J.P. Dumanski et al.

    Molecular genetic analysis of chromosome 22 in 81 cases of meningioma

    Cancer Res

    (1990)
  • R. Eldridge

    Central neurofibromatosis with bilateral acoustic neuroma

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