A detailed multipoint gene map of chromosome 1q

doi:10.1016/0888-7543(90)90220-O

Genomics

Volume 8, Issue 1, September 1990, Pages 13-21

https://doi.org/10.1016/0888-7543(90)90220-O Get rights and content

Abstract

Utilizing genotyping data for 23 markers, we have constructed a 21-locus multipoint genetic map of the long arm of chromosome 1. Five new RFLPs are reported. The map integrates anonymous loci from previous primary linkage maps and incorporates markers for 10 coding sequences. These markers form a continuous linkage group of 85 cM in males and 141 cM in females. The map was constructed employing the LINKAGE and CRIMAP computational methodologies via a stepwise algorithm.

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We have identified genetic variation within two human genes, transforming growth factor-β2 (TGFB2) and the homeobox gene HB24 (HLX1). Reported here are four human RFLPs and SSCPs for TGFB2 in humans and gorillas. In addition, we describe an RFLP and a SSCP for HLX1. We propose that HLX1 is the human homologue of the mouse homeobox gene Hlx based on extensive sequence homology between the genes and the close proximity of both genes to TGFB2 in their respective species. We also report the chromosomal localization of HLX1 to the long arm of human chromosome 1. Finally, utilizing the polymorphisms described for TGFB2 and HLX1, we have been able to localize these genes within a framework map of the distal long arm of chromosome 1 and to study the linkage relationship between these two genes. Pairwise linkage analysis shows that these two genes are linked, with a recombination fraction of 3.1% and a lod score of 14.49.
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This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of human chromosome 1. The map contains 101 loci defined by genotypes generated from CEPH family DNAs with 146 different contributions from 11 laboratories. A total of 58 loci are uniquely placed on the map with likelihood support of at least 1000:1. The map extends from loci in the terminal bands of both chromosome arms (locus D1Z2 in 1p36.3 and D1S68 in 1q44) and is anchored at the centromere by the D1Z5 α-satellite polymorphism. With the exception of a single locus, the remaining loci are arrayed on the fixed map in short intervals and their possible locations are indicated. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 308, 478, and 390 cM, respectively. The sex-averaged map contains only four intervals > 15 cM, and the mean genetic distance between the 58 uniquely placed loci is 6.7 cM.
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A detailed multipoint gene map of chromosome 1q

Abstract

Cell

Anal. Biochem

Anal. Biochem

Nucleic Acids Res

Cloning and expression of the cDNA for human antithrombin III

Nucleic Acids Res

Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins

Nature (London)

Organization of the genes encoding complement receptors type 1 and 2, decayaccelerating factor, and C4-binding protein in the RCA locus on human chromosome 1

J. Exp. Med

Segregation of genetic markers in families with chromosome polymorphisms and structural rearrangements involving chromosome 1

Ann. Hum. Genet

Probable assignment of the Duffy blood group locus to chromosome 1 in man

A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome 1

Amer. J. Hum. Genet

The interpretation of lod scores in linkage analysis

Hum. Genet. Meeting

A sharper Bonferroni procedure for multiple tests of significance

Biometrika

Isolation and mapping of a polymorphic DNA sequence (pHHH119) on chromosome 1 (D1S59)

Nucleic Acids Res

Three RFLPs are detected by an alpha spectrin genomic clone

Nucleic Acids Res

Identification of the cystic fibrosis gene: Genetic analysis

Science

Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms

Cytogenet. Cell Genet

Chromosomal localization of the human apoprotein CI gene and of a polymorphic apoprotein AII gene

Biochem. Biophys. Res. Commun

Construction of multilocus genetic linkage maps in humans