Speciation of non-transferrin-bound iron ions in synovial fluid from patients with rheumatoid arthritis by proton nuclear magnetic resonance spectroscopy

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  • The influence of sample collection, handling and low temperature storage upon NMR metabolic profiling analysis in human synovial fluid

    2021, Journal of Pharmaceutical and Biomedical Analysis
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    The analysis of free iron ions in synovial fluid using NMR spectroscopy led to the conclusion that the sample was stable during storage. Samples were collected into heparinised tubes and stored at −70 °C, the storage period was not stated [20]. Two reports gave the metabolic features of RA and inflammation in synovial fluid, both analysed by NMR spectroscopy [21,22].

  • Detection and identification of the oxidizing species generated from the physiologically important Fenton-like reaction of iron(II)-citrate with hydrogen peroxide

    2019, Archives of Biochemistry and Biophysics
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    Under some pathological conditions, the nontransferrin-bound iron is mainly bound by citrate [33,35]. Iron-citrate complexes are also found in synovial fluid from patients with rheumatoid arthritis and in the blood serum of patients under pathological conditions of iron overload [33,35–37]. On the other hand, in vivo H2O2 can be produced by enzymes, such as xanthine oxidases and superoxide dismutase.

  • Ascorbate and ferritin interactions: Consequences for iron release in vitro and in vivo and implications for inflammation

    2019, Free Radical Biology and Medicine
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    A rise in intracellular LIP could synergise ascorbate-dependent iron release from ferritin and precipitate ferroptosis [4,35,162–165]. This signifies that a rise in LIP such as that found in arthritis [166–169] or in cancer therapy [170,171] is required to act as a synergist with LIP to precipitate ferroptosis [164]. Although we know much about the redox chemistry of ferritin, there is still much more to learned about ferritins’ enzyme activity in relation to its ascorbate oxidase and peroxidase activities and probably superoxide dismutase and catalase activities as found recently with Prussian Blue nanoparticles and hematite particles [149,160,172].

  • Labile iron potentiates ascorbate-dependent reduction and mobilization of ferritin iron

    2017, Free Radical Biology and Medicine
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    This explains why ascorbate alone is not notably pro-oxidant [34]. Raised levels of total iron have been detected in synovial tissue and fluid from patients with rheumatoid arthritis [112–115] and of ascorbate free radicals with EPR [49,113,116]. In inflammation and with cancer therapy raised ascorbate levels can have a pro-oxidant effect [21,49,54,117–120].

  • Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B

    2015, Geochimica et Cosmochimica Acta
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    Given that acidic functional groups in citrate such as carboxyls and hydroxyls represent the major metal-binding sites in natural organic matter (Tipping, 2002), however, the kinetic model developed in this study will be useful for understanding and assessing the detailed processes of ligand exchange in natural waters. Because citrate is an important biosynthesized molecule, our results provide insights not only into the transformation and availability of Fe in natural systems but also Fe transportation and uptake in plants (Tiffin, 1966; Pierre and Gautier-Luneau, 2000), pathogenic bacteria (Guerinot et al., 1990; Ochs et al., 1995), and blood plasma (Parkes et al., 1991; Evans et al., 2008). In this study, the effect of ionic strength on ligand exchange kinetics between mononuclear ferric citrate complexes and DFB was theoretically and experimentally investigated in the NaCl concentration range of 0.01–0.5 M.

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