Analysis of a clinically important interaction between phenytoin and Shankhapushpi, an Ayurvedic preparation
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2015, Epilepsy and BehaviorCitation Excerpt :Besides, patients already on AEDs enhance their risk of toxicity by ingesting botanicals that may also compromise AED activity [108,109]. Drug–herbal interactions have been demonstrated for some herbal preparations and AEDs, for example Shankpushpi, an Ayurvedic medication, which interacts with phenytoin, lowering its serum levels and, thus, increasing the likelihood of seizures [108]. Similarly, Mentat (BR16A) [110], another Ayurvedic medication, when administered with phenytoin, suppresses the latter's metabolism and, when given with carbamazepine, increases its bioavailability [109].
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