Deaf animal models for studies of a multichannel cochlear prosthesis
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Cited by (48)
Intracochlear near infrared stimulation: Feasibility of optoacoustic stimulation in vivo
2019, Hearing ResearchCitation Excerpt :Acute deafening by intra-scalar infusion of neomycin sulfate solution (2.5–5%) abolished all responses to acoustic stimulation, within minutes after infusion (compare Snyder et al., 2004; Middlebrooks and Bierer, 2002; Miller, 2001; Leake-Jones et al., 1982). In the current study, neomycin infusion was performed at the end of the experiments, with approximately 2 h of recordings after deafening, sufficient for data collection but too brief for allowing functional effects of neomycin on SGNs (Leake-Jones et al., 1982). Supporting this, electric stimulation at current levels that were in a typical range for acutely pharmacologically deafened guinea pigs (Sato et al., 2016; Snyder et al., 2004, 2008; Miller et al., 1993, 1998) resulted in the expected responses and confirmed the good function of the auditory nerve.
Chapter 18 Cochlear implants: cortical plasticity in congenital deprivation
2006, Progress in Brain ResearchCitation Excerpt :In neonatally deafened animals, the destruction of the inner ear is achieved by systemic application of ototoxic substances during the phase of hearing acquisition. The advantage of neonatally deafened animals is the easy availability, and the disadvantage is the pronounced and rapid degeneration of spiral ganglion cells (cell loss from 50–90% of normal counts after several weeks to months of deafness, see Leake-Jones et al., 1982; Leake et al., 1987, 1999; Leake and Hradek, 1988; Dodson, 1997a, b, 2000). It is an important advantage of congenitally deaf strains that some of them show a slow degeneration of spiral ganglion cells, comparable to human congenital deafness.
Auditory response to intracochlear electric stimuli following furosemide treatment
2003, Hearing Research