The electrokinetic properties of phospholipid stabilized fat emulsions VI. Zeta potentials of Intralipid 20% in TPN mixtures
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Physical characterisation of drug encapsulated soybean oil nano-emulsions
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :There are some similarities amongst the zeta potential profiles. In all cases, the zeta potential becomes more negative with increasing pH, as expected from acid-base charging mechanisms [38,39]. In most cases, the zeta potential became less negative following encapsulation.
Physical Characterization of Halofantrine-Encapsulated Fat Nanoemulsions
2019, Journal of Pharmaceutical SciencesCitation Excerpt :The absolute zeta potential for most pH values is greater than ǀ30ǀ mV, the value often considered enough to impart significant electrostatic stability, and in many cases greater than ǀ50ǀ mV, the value considered enough to impart full electrostatic stability.3,35,40 Zeta potential, as a function of pH, follows a reverse sigmoidal pattern with high positive values at low pH and high negative values at high pH, consistent with literature results for many such systems.3,46,71 The drug-free fat emulsion exhibited an isoelectric point (pHi.e.p.)
The role of lecithin degradation on the pH dependent stability of halofantrine encapsulated fat nano-emulsions
2017, International Journal of PharmaceuticsCitation Excerpt :into 1 × 10−3 M KNO3 using milliQ water which had been filtered (0.2 μm filter) prior to use. Washington (1992) and Carasso and Rowlands (1995), amongst others, have shown that the zeta potential of Intralipid® is unaffected by dilution immediately prior to measurement. The zeta potential is, however, strongly affected by pH and we have therefore measured values as a function of pH rather than a single value at the native pH.
A concentric cylinder shear device for the study of stability in intravenous emulsions
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