Elsevier

Toxicology Letters

Volume 12, Issue 1, June 1982, Pages 53-57
Toxicology Letters

Toxicity of chromium salts to cultured mouse embryos

https://doi.org/10.1016/0378-4274(82)90198-9Get rights and content

Abstract

Teratogenic effects caused by hexavalent and trivalent chromium were compared in cultured mouse embryos. Blastocyst formation was more strongly affected by the two hexavalent salts (K2Cr2O7, CaCrO4) than by the trivalent one [Cr(NO3)3], and more by K2Cr2O7 than by CaCrO4. The hexavalent salts were also more effective in inhibiting hatching of the blastocyst from the zona pellucida and formation of the inner cell mass. The compound most powerful in inhibiting formation of the inner cell mass was CaCrO4.

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