Short communicationTranscriptional regulation in the Chlamydia trachomatis pCT plasmid
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Cited by (22)
Expression of Chlamydia muridarum plasmid genes and immunogenicity of pGP3 and pGP4 in different mouse strains
2014, International Journal of Medical MicrobiologyCitation Excerpt :TCA04 and TCA05 are known to encode the pGP3 and pGP4 proteins, respectively. It has been described that all plasmid-borne genes are transcribed and translated in the case of C. trachomatis (Ricci et al., 1995). pGP3, one of the plasmid-encoded proteins, is secreted into the cytosol during C. trachomatis infection and has been found to be recognized by human antibodies (Chen et al., 2010).
Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae
2013, Nanomedicine: Nanotechnology, Biology, and MedicineCitation Excerpt :That plasmid was designated pGFP-EG(KG) and was demonstrated to lack all antibiotic resistance by experiments congruent to those outlined above. The full DNA sequence of the 7.5 kbp plasmid has been published, and many aspects of expression of plasmid genes have been described.e.g.,14,43–45 For reasons developed below, we deduced that governance of transcript production from glgA must reside in one or more of the plasmid genes pL2-01, pL2-04, pL2-05, and pL2-06. To determine which of these is/are involved in transcriptional control of glgA, we prepared a mutant in the pCL2-EG(KG) plasmid for each gene above using a PCR-based method.46
Assessment of the load and transcriptional dynamics of Chlamydia trachomatis plasmid according to strains' tissue tropism
2013, Microbiological ResearchCitation Excerpt :This regulation is believed to be carried out by a hypothetical active partitioning system, given the sequence homology of the plasmid ORF7/pgp5 with the sopA and parA genes of other bacteria encoding partitioning proteins (Williams and Thomas, 1992; Thomas et al., 1997; Bignell and Thomas, 2001). Intriguingly, deletion mutagenesis assays suggest that ORF7/pgp5 is not essential for plasmid maintenance (Song et al., 2013), contrarily to ORF8/pgp6 which is likely co-transcribed with the former (Ricci et al., 1995). Considering that partitioning systems are known to involve co-transcribed genes (e.g. sopA/sopB and parA/parB) (Hiraga, 1992), and that both ORF7/pgp5 and ORF8/pgp6 presented higher expression levels mostly at the mid stage of the developmental cycle (Fig. 3) (where the products of these ORFs are likely needed for plasmid segregation accomplishment), we speculate that ORF8/pgp6 may play a role in plasmid transmission.
Identification and characterization of promoters regulating tuf expression in Chlamydia trachomatis serovar F
2000, Archives of Biochemistry and BiophysicsRobust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor
2022, Frontiers in MicrobiologyThe repressor function of the chlamydia late regulator EUO is enhanced by the plasmid-encoded protein Pgp4
2020, Journal of Bacteriology