Brief noteCloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils☆
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Cited by (36)
Leukotrienes and lipoxins
2012, Bioactive LipidsFormyl-peptide receptor like 1: A potent mediator of the Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> current I<inf>CRAC</inf>
2008, Archives of Biochemistry and BiophysicsCitation Excerpt :Assays of Ca2+ mobilization have provided a useful approach to identify ligands for chemoattractant receptors [45]. Formyl-peptide receptor like 1 (FPRL1) was originally cloned as an orphan receptor [6] but was subsequently found to mediate Ca2+ mobilization in response to high concentrations of the bacterial chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) [46]. Our previous studies and some other researches indicated that the inhibition of inflammatory responses as well as the release of the proinflammatory cytokine effects of lipoxin A4 (LXA4), BML-111 and annexin A1 (ANXA1) were subsequently found attributed to the activation of FPRL1 (or LXA4R, ALXR) [19,21,35].
Regulatory expression of lipoxin A<inf>4</inf> receptor in physiologically estrus cycle and pathologically endometriosis
2005, Biomedicine and PharmacotherapyCitation Excerpt :Furthermore, LXA4 was detected in inflammatory exudates in response to inflammatory challenge [14] and the endogenous production in vivo was reported in inflammatory diseases in lung [15], kidney [16], and stomach [17] to exert anti-inflammatory activity. On the other hand, specific receptor for LXA4 with high affinity has also cloned from myeloid lineages [18–20]. The receptor belongs to G-protein coupled receptor and widely distributes in cells and tissues [18].
Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R
2003, BloodCitation Excerpt :We have shown, for the first time, that the G protein–coupled receptor FPRL1/LXA4R mediates the cytokinelike properties of SAA. FPRL1/LXA4R was originally identified as a low-affinity receptor forN-formyl-Met-Leu-Phe that shares 69% sequence identity with the high-affinity formyl peptide receptor FPR.23,45-47 It was subsequently reported that LXA4 and aspirin-triggered 15-epi-LXA4 are endogenous ligands for FPRL1/LXA4R and exert their anti-inflammatory functions through this receptor.44
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On request, the authors will supply detailed experimental evidence for the conclusions reached in this Brief Note.