Elsevier

Gene

Volume 118, Issue 2, 10 September 1992, Pages 303-304
Gene

Brief note
Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils

https://doi.org/10.1016/0378-1119(92)90208-7Get rights and content

Abstract

We cloned a cDNA (RFP) encoding a receptor (RFP) related (70% overall nucleotide homology) to the formyl peptide receptor of human neutrophils (hFPR). RFP is a seven-transmembrane-domain receptor and its distribution is limited to myeloid cells. Domain sequence comparison with hFPR reveals highly conserved regions and provides clues to putative domains involved in ligand binding and receptor desensitization.

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On request, the authors will supply detailed experimental evidence for the conclusions reached in this Brief Note.

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