Elsevier

Gene

Volume 98, Issue 1, 1 February 1991, Pages 141-145
Gene

Short communication
Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1

https://doi.org/10.1016/0378-1119(91)90117-TGet rights and content

Abstract

The Saccharomyces cerevisiae L YS2 gene, which encodes α-aminoadipate reductase, an essential enzyme in the yeast lysine biosynthetic pathway, has been sequenced. A large open reading frame (ORF) has been identified which can specify a 1392-amino acid protein with a deduced Mr of 155 344. A DNA database search using the translated LYS2 ORF as a probe has revealed significant aa sequence homology to the Bacillus brevis enzyme tyrocidine synthetase 1.

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Present address: Program in Neuroscience, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115 (U.S.A.).

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