Elsevier

Brain Research Bulletin

Volume 26, Issue 1, January 1991, Pages 155-160
Brain Research Bulletin

Article
Tachykinin receptor subtypes involved in the central effects of tachykinins on water and salt intake

https://doi.org/10.1016/0361-9230(91)90201-TGet rights and content

Abstract

The present study was aimed at investigating which tachykinin receptor subtypes mediate the inhibitory effects of tachykinins a) on salt intake induced by sodium depletion, b) on water intake induced by subcutaneous hypertonic NaCl administration and c) on water intake induced by central angiotensin II injection. The study was carried out by evaluating the potency of action, following intracerebroventricular injection, of several peptides, including both naturally occurring tachykinins and synthetic peptides selective for a given receptor subtype. The results obtained show different rank orders of potency of the agonists in the different behavioral tests, thus suggesting that different receptor subtypes are involved in the effects of tachykinins on water and salt intake. NK-3 receptors appear to be involved in the inhibitory effect of tachykinins on depletion-induced salt appetite. NK-2 receptors apparently mediate the inhibitory effect of tachykinins on drinking induced by hyperosmotic NaCl administration, while NK-1 receptors are probably involved in the inhibition of angiotensin H-induced drinking.

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  • Decreases in neurokinin-3 tachykinin receptor-immunoreactive and -mRNA levels are associated with salt appetite in the deoxycorticosterone-treated rat

    2003, Brain Research
    Citation Excerpt :

    Similarly, sodium depletion through treatment with the diuretic furosemide induces increased intake of a concentrated salt solution the rat [37]. Using both the DOCA and furosemide models, investigators have examined a number of brain regions in an attempt to elucidate the underlying neurochemical basis for salt seeking/craving/appetitive behavior [9,11,26,28–30]. These regions include the prefrontal cortex, nucleus accumbens (Acb), bed nucleus of the stria terminalis (BNST), medial amygdala (MeA), paraventricular nucleus of the hypothalamus (PVN), hippocampus (Hp), parabrachial nucleus (PBN), and nucleus tractus solitarius (NTS).

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This article was presented at the Xth International Congress on the Physiology of Food and Fluid Intake held in Paris, France, July 4–8, 1989. Other selected articles from this meeting have been published in Physiology & Behavior, Volume 48, Number 6, 1990, Volume 49, Number 1, 1991 and Brain Research Bulletin, Volume 25, Number 6, 1990.

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