Elsevier

Medical Hypotheses

Volume 45, Issue 5, November 1995, Pages 449-454
Medical Hypotheses

The hypothetical epidemic of coronary heart disease and atherosclerosis

https://doi.org/10.1016/0306-9877(95)90219-8Get rights and content

Abstract

Accurate usage of the term ‘epidemic’ is important scientifically and it should ideally be used to mean only contagious diseases, not used loosely or emotively to mean non-infectious diseases, particularly coronary heart disease, which is a non-specific complication of many diseases. It should not be used as a surrogate term for atherosclerosis of indefinite severity. An epidemic of atherosclerosis is impossible, there being no variation in prevalence because the disease is ubiquitous. Moreover, vital statistics are too unreliable to determine the existence of an increase or decline in coronary heart disease. A coronary heart disease epidemic could be due to an increase in non-atherosclerotic coronary heart disease or increased severity of atherosclerosis. The former has not been studied and the latter would cause a shift to the left in age distribution and is inconsistent with the fall in ‘all cause’ and stroke mortality rates whilst coronary heart disease mortality allegedly increased alarmingly. A coronary heart disease epidemic, having no scientific basis, negates any reason for the sustained search for a speculative causative environmental factor.

References (55)

  • T. Strasser

    Atherosclerosis and coronary heart disease: the contribution of epidemiology

    WHO Chronicle

    (1972)
  • W. Little et al.
  • J.M. Last

    A Dictionary of Epidemiology

    (1988)
  • J. Walton et al.
  • W.E. Stehbens

    Pathology of the Cerebral Blood Vessels

    (1972)
  • L.N. Katz et al.

    Experimental Atherosclerosis

    (1953)
  • L. Thomas

    An epidemic of apprehension

    Discover

    (1983)
  • W.L. Proudfit

    Origin of concept of ischaemic heart disease

    Br Heart J

    (1983)
  • J.L. Steven

    Fibroid degeneration and allied lesions of the heart, and their association with disease of the coronary arteries

    Lancet

    (1987)
    J.L. Steven

    Fibroid degeneration and allied lesions of the heart, and their association with disease of the coronary arteries

    Lancet

    (1987)
    J.L. Steven

    Fibroid degeneration and allied lesions of the heart, and their association with disease of the coronary arteries

    Lancet

    (1987)
  • J.S. McCormick

    James MacKenzie and coronary heart disease

    J R Coll Gen Pract

    (1981)
  • J.B. Herrick

    Clinical features of sudden obstruction of the coronary arteries

    JAMA

    (1912)
  • J.B. Herrick et al.

    Angina pectoris. Clinical experience with two hundred cases

    JAMA

    (1918)
  • J.B. Herrick

    Thrombosis of the coronary arteries

    JAMA

    (1919)
  • A.H.T. Robb-Smith

    The Enigma of Coronary Heart Disease

    (1967)
  • H.C. Atkinson

    The changing emphasis in heart disease

    JAMA Georgia

    (1938)
  • I.H. Page et al.

    Atherosclerosis and the fat content of the diet

    Circulation

    (1957)
  • Cited by (11)

    • Helicobacter and atherosclerosis

      1999, American Heart Journal
    • An epidemic of coronary heart disease

      2012, QJM: An International Journal of Medicine
    View all citing articles on Scopus
    View full text