Review
Retroviral insertional mutagenesis as a strategy to identify cancer genes

https://doi.org/10.1016/0304-419X(95)00020-GGet rights and content

First page preview

First page preview
Click to open first page preview

References (411)

  • J.M. Adams et al.

    Biochim Biophys Acta

    (1991)
  • L.M. Albritton et al.

    Cell

    (1989)
  • P. Bates et al.

    Cell

    (1993)
  • J.F. Bazan

    Biochem Biophys Res Commun

    (1989)
  • Y. Ben-David et al.

    Cell

    (1991)
  • D. Bergeron et al.

    Virology

    (1992)
  • N. Casadevall et al.

    J Biol Chem

    (1991)
  • R.M. Cawthon et al.

    Genomics

    (1991)
  • B. Chesebro et al.

    Virology

    (1985)
  • S.Y. Choi et al.

    J Biol Chem

    (1994)
  • S. Chretien et al.

    Blood

    (1994)
  • N. Clausse et al.

    Virology

    (1993)
  • J.M. Coffin et al.

    Trends Genet

    (1990)
  • L.M. Corcoran et al.

    Cell

    (1984)
  • R. Craigie

    Trends Genet

    (1992)
  • A. D'Andrea et al.

    Biochim Biophys Acta

    (1992)
  • A.D. D'Andrea et al.

    Cell

    (1989)
  • C. Dickson et al.

    Cell

    (1984)
  • P. Acland et al.

    Nature

    (1990)
  • J.M. Adams et al.

    Science

    (1991)
  • J.M. Adams et al.

    Nature

    (1985)
  • H.T. Adler et al.

    J. Virol

    (1988)
  • P.N. Adler et al.

    Dev Genet

    (1989)
  • S. Aizawa et al.

    EMBO J

    (1990)
  • A.M. Al-Salameh et al.

    J Virol

    (1992)
  • L.M. Alkema et al.

    Nature

    (1995)
  • M.J. Alkema et al.

    Hum Mol Genet

    (1993)
  • H. Amanuma et al.
  • D.S. Askew et al.

    Oncogene

    (1991)
  • D.S. Askew et al.

    Mol Cell Biol

    (1994)
  • G.B. Athas et al.

    Crit Rev Oncog

    (1994)
  • V. Baldin et al.

    EMBO J

    (1990)
  • J.K. Ball et al.

    J Virol

    (1988)
  • C.S. Barker et al.

    J Virol

    (1992)
  • C. Bartholomew et al.

    Mol Cell Biol

    (1991)
  • C. Bartholomew et al.

    Oncogene

    (1989)
  • W.R. Baumbach et al.

    J Virol

    (1988)
  • S.E. Bear et al.
  • A. Bellacosa et al.

    J Virol

    (1994)
  • A. Bellacosa et al.
  • Y. Ben David et al.

    Oncogene

    (1988)
  • Y. Ben-David et al.

    Mol Cell Biol

    (1992)
  • Y. Ben-David et al.
  • Y. Ben-David et al.

    Genes Dev

    (1991)
  • Y. Ben-David et al.

    New Biol

    (1990)
  • D. Bergeron et al.

    Leukemia

    (1993)
  • D. Bergeron et al.

    J Virol

    (1991)
  • A. Berns

    J Cell Biochem

    (1991)
  • R. Bestwick et al.

    J Virol

    (1984)
  • J.M. Bishop

    Science

    (1987)
  • Cited by (176)

    • Transposons As Tools for Functional Genomics in Vertebrate Models

      2017, Trends in Genetics
      Citation Excerpt :

      Cut-and-paste DNA transposons, including SB and PB, have been used to introduce random insertion mutations in tissues of mice for the purpose of inducing cancer and identifying cancer genes [122] (see Supplementary Table S1 online). These studies were initially motivated by older research showing that some retroviruses could establish chronic infections in animals and induce the formation of cancer via insertional mutagenesis [123]. These so-called slow-transforming retroviruses (retroviruses that cause tumors after a latency period of 3–9 months [124]) can induce mammary tumors, leukemia, lymphoma, and certain other types of cancer in sensitive species.

    • Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

      2013, Translational Research
      Citation Excerpt :

      Murine leukemia viruses can cause cancer by acting as an insertional mutagen, either inserting near and activating proto-oncogenes or inserting within and inactivating tumor suppressor genes.154 The features of the integrated provirus that can cause these effects on endogenous genes, are the enhancer and promoter sequences within the LTR, the splice donor and acceptor within the body of the virus, or the polyadenylation site within the long terminal repeat.155-157 The tumor DNAs can be used to isolate new candidate cancer genes, by using the integrated provirus as a molecular tag.

    • Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

      2010, Blood
      Citation Excerpt :

      The above studies indicate increased leukemia susceptibility in Runx1-deficient conditions, and at the same time clearly suggest that Runx1-deficient cells require additional genetic changes for leukemic transformation. Retroviral insertional mutagenesis (RIM) is a powerful tool to identify oncogenes and tumor suppressor genes.19 Injection of replication-competent retrovirus into newborn mice leads to integration of virus into the host genome and activation of oncogenes or disruption of tumor suppressor genes, resulting in leukemia or lymphoma.

    • Early T cell differentiation: Lessons from T-cell acute lymphoblastic leukemia

      2010, Progress in Molecular Biology and Translational Science
    View all citing articles on Scopus
    View full text