Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
ReviewRetroviral insertional mutagenesis as a strategy to identify cancer genes
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Transposons As Tools for Functional Genomics in Vertebrate Models
2017, Trends in GeneticsCitation Excerpt :Cut-and-paste DNA transposons, including SB and PB, have been used to introduce random insertion mutations in tissues of mice for the purpose of inducing cancer and identifying cancer genes [122] (see Supplementary Table S1 online). These studies were initially motivated by older research showing that some retroviruses could establish chronic infections in animals and induce the formation of cancer via insertional mutagenesis [123]. These so-called slow-transforming retroviruses (retroviruses that cause tumors after a latency period of 3–9 months [124]) can induce mammary tumors, leukemia, lymphoma, and certain other types of cancer in sensitive species.
Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy
2013, Translational ResearchCitation Excerpt :Murine leukemia viruses can cause cancer by acting as an insertional mutagen, either inserting near and activating proto-oncogenes or inserting within and inactivating tumor suppressor genes.154 The features of the integrated provirus that can cause these effects on endogenous genes, are the enhancer and promoter sequences within the LTR, the splice donor and acceptor within the body of the virus, or the polyadenylation site within the long terminal repeat.155-157 The tumor DNAs can be used to isolate new candidate cancer genes, by using the integrated provirus as a molecular tag.
What we have learned about pancreatic cancer from mouse models
2012, GastroenterologyStem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
2010, BloodCitation Excerpt :The above studies indicate increased leukemia susceptibility in Runx1-deficient conditions, and at the same time clearly suggest that Runx1-deficient cells require additional genetic changes for leukemic transformation. Retroviral insertional mutagenesis (RIM) is a powerful tool to identify oncogenes and tumor suppressor genes.19 Injection of replication-competent retrovirus into newborn mice leads to integration of virus into the host genome and activation of oncogenes or disruption of tumor suppressor genes, resulting in leukemia or lymphoma.
Molecular cytogenetic analysis of feline leukemia virus insertions in cat lymphoid tumor cells
2010, Journal of Virological MethodsEarly T cell differentiation: Lessons from T-cell acute lymphoblastic leukemia
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