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A possible role for the species peroxonitrite in intrification

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Cited by (18)

  • Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of trypanosoma cruzi iron-superoxide dismutases (fe-sods) a and b : Disparate susceptibilities due to the repair of tyr35 radical by cys83 in fe-sodb through intramolecular electron transfer

    2014, Journal of Biological Chemistry
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    Peroxynitrite was synthesized in a quenched flow reactor from sodium nitrite and hydrogen peroxide (H2O2) under acidic conditions and quantitated as described previously; excess H2O2 was removed by treatment with MnO2, and NO2− contamination was always <20% (22). Peroxynitrite concentration was determined spectrophotometrically at 302 nm (ϵ302 nm = 1670 m−1 cm−1) (23). The spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and the anti-DMPO rabbit antiserum were kindly provided by Dr. Ronald Maison (NIEHS, National Institutes of Health, Bethesda, MD).

  • Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases

    2021, Redox Biology
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    Nitric oxide (•NO) is a slowly reacting molecule, with a high relevance as signaling molecule. However, nitric oxide reacts with superoxide at a high rate constant to give peroxynitrite (ONOO−), able to decompose spontaneously to yield nitrogen dioxide (•NO2) and hydroxyl radicals [2]. Under normal circumstances, the formation and subsequent degradation of reactive species is regulated by cellular defense systems, including scavenging enzymes able to remove oxidants or their precursors such as superoxide dismutases, catalase, thioredoxin/thioredoxin reductase, and glutathione peroxidase.

  • Synthesis of peroxynitrite from nitrite and hydrogen peroxide

    2005, Methods in Enzymology
    Citation Excerpt :

    A simpler method of synthesis was first performed in 1902 when Baeyer and Villiger (1901) published a method of mixing nitrite with hydrogen peroxide. In 1968, other authors (Hughes and Nicklin, 1968, 1970a,b; Hughes et al., 1971) reported a synthesis also based on the reaction between nitrite and hydrogen peroxide in which the hydrogen peroxide was “thrown” into a nitrite solution and produced peroxynitrite in yields between 40 and 50%. In 1973, Reed et al. (1974) reported a method of reacting nitrite and hydrogen peroxide in a quenched flow reactor.

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