Laser-evoked potentials after painful hand and foot stimulation in humans: evidence for generation of the middle-latency component in the secondary somatosensory cortex
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2019, Handbook of Clinical NeurologyAnodal Transcutaneous Spinal Direct Current Stimulation (tsDCS) Selectively Inhibits the Synaptic Efficacy of Nociceptive Transmission at Spinal Cord Level
2018, NeuroscienceCitation Excerpt :The cortical generators of the early-latency LEP-N1 remains a matter of debate. Source analysis studies have suggested a contribution of the primary somatosensory cortex (S1) and bilateral secondary somatosensory cortices (S2) (Tarkka and Treede, 1993; Xu et al., 1995; Spiegel et al., 1996; Valeriani et al., 1996; 2000; Garcia-Larrea et al., 2003; Valentini et al., 2012). Considering that in S1, the representation of the foot is more medial as compared to the hand, the contribution of S1 activity to the LEP-N1 might be strongly dependent on the location of the nociceptive stimulus.
Temporal Profile and Limb-specificity of Phasic Pain-Evoked Changes in Motor Excitability
2018, NeuroscienceCitation Excerpt :In contrast, when the laser stimulus was delivered 100 ms before the TMS pulse, the nociceptive input conveyed by myelinated Aδ fibers has enough time to interact with the descending motor volley at spinal level, but it does not have enough time to interact at cortical level. Indeed, studies have shown that the first cortical response to laser stimuli delivered to the hand dorsum occurs approximately 140–180 ms after onset (Xu et al., 1995; Spiegel et al., 1996; Valentini et al., 2012a,b; Lenoir et al., 2017). Moreover, depth recordings performed in epileptic patients have shown that laser stimuli delivered to the hand dorsum can elicit responses in M1 starting approximately 120 ms after stimulation onset, and peaking 170 ms after stimulation onset (Frot et al., 2013).
Empathy Predicts an Experimental Pain Reduction During Touch
2016, Journal of PainCitation Excerpt :This indicates a neural inhibitory interaction between tactile and pain stimuli at the spinal level. Spatially closed tactile stimulation also suppress N1 pain-evoked potentials,54 which is known to be correlated with the magnitude of the noxious stimulation and the perceived pain intensity, and also reflects the arrival of the ascending nociceptive information to the SI.25,28,74,76 It has been recently suggested that the level of empathy predicts brain activation in SI when seeing a hand being touched during painful stimulation application,9,56,70 suggesting an involvement of the sensory-discriminative cortex in empathy for pain.
Somatosensory Evoked Potentials
2012, Aminoff's Electrodiagnosis in Clinical Neurology
This study was supported by the Deutsche Forschungsgemeinschaft (Tr 236/6).
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We appreciate the technical assistance of G. Günther and G. Schatt.