Glucocorticoid treatment increases the ability of CRH to induce seizures
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Cited by (28)
Interactive effects of prenatal exposure to restraint stress and alcohol on pentylenetetrazol-induced seizure behaviors in rat offspring
2016, AlcoholCitation Excerpt :With respect to epileptic behaviors, in the present study, the COS blood levels and the number, duration, and occurrence of the focal and tonic-clonic seizures significantly increased in pups of the RS group compared to the control pups, which in general indicates potentiation of seizure behaviors in the stressed pups. These results are consistent with those of previous studies that showed the effect of stress on seizure susceptibility to be at least in part due to involvement, activities, and engagement of the HPA system (Edwards et al., 2002; Maguire & Salpekar, 2013; Reddy & Rogawski, 2002; Rosen et al., 1994; Sadaghiani & Saboory, 2010; Yang, Zou, Wang, & Ding, 2011). The significantly elevated COS levels in pups of the RS group on P6 and P15 clearly indicate that they were exposed to stress during gestation.
Evolutionary conservation of glucocorticoids and corticotropin releasing hormone: Behavioral and physiological adaptations
2011, Brain ResearchCitation Excerpt :In many species (primates, rodents, reptiles, and amphibians), CRH is expressed in the amygdala, bed nucleus of the stria terminalis (BNST), and medial pallium, and its expression, and that of the immediate early gene c-fos, are increased following exposure to a stressor as well as the level of corticosterone being elevated (Yao et al., 2008a, 2008b; Denver and Crespi, 2006). CRH and corticosterone are well known across phyla to promote locomotor activity and impact diverse forms of behaviors (Moore and Rose, 2002; Rosen et al., 1994; Wingfield, 2004) including sexual, feeding and fear related behaviors among others. In the frog, just like mammals, CRH is increased by treatment with corticosterone (given in their bathing water over several days).
Scopolamine-induced convulsions in fasted mice after food intake: Evaluation of the sedative effect in the suppression of convulsions
2010, Epilepsy ResearchCitation Excerpt :It has been shown that after fasting for 12, 24 and 48 h, the stress hormone corticosterone level rises in mice (Luque et al., 2007) and CRH (corticotropin-releasing hormone) release increases in rats deprived of food for 48 h (Maeda et al., 1994). Since animals develop convulsions after CRH administration (Rosen et al., 1994) or exposure to stress (Rhodes et al., 2004), we used different attempts during deprivation period to counter food deprivation-induced neuroendocrine responses for the prevention of seizures in fasted animals. However, neither dexamethasone use to suppress pituitary–adrenocortical activity (Gomez et al., 1998), nor clonidine and diazepam use to ameliorate stress during deprivation could provide effective treatments in convulsions in 48-h (Enginar and Nurten, 2005) and 24-h (unpublished data of a thesis study) fasted animals, respectively.
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
2006, Progress in NeurobiologyA neuroendocrine mechanism for sustaining fear
2005, Trends in NeurosciencesStress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala
2004, Physiology and Behavior