Wobble position modified nucleosides evolved to select transfer RNA codon recognition: A modified-wobble hypothesis
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Cited by (94)
Inosine and its methyl derivatives: Occurrence, biogenesis, and function in RNA
2022, Progress in Biophysics and Molecular BiologyStructural snapshots of CmoB in various states during wobble uridine modification of tRNA
2021, Biochemical and Biophysical Research CommunicationsCitation Excerpt :For example, the uridine at the wobble position can read the G-ending codon in addition to the A-ending codon. Generally, a modification of wobble nucleoside within tRNA further confers a unique decoding property to anticodon [2–4], and numerous post-transcriptional modifications discovered since then added extra layers of complexity to the original model by Crick [5–9]. In particular, wobble uridines are frequently modified, for example, to 5-carboxymethoxyuridine (cmo5U) or 5-methoxyuridine (mo5U) in Gram-negative or Gram-positive bacteria, respectively.
Importance of a tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing in tRNA<inf>CGG</inf><sup>Pro</sup> for decoding
2019, Journal of Biological ChemistryCitation Excerpt :Nucleotide 37 of the tRNA is located 3′ to the anticodon, adjacent to the first position of the Watson–Crick base pair between the codon and anticodon nucleotide 36 (Fig. 1A). The codon–anticodon pairing between tRNAUUULys and its codon is weak in the absence of the modifications because of the three A-U base pairs and poor stacking of the UUU anticodon (15). Both the t6A and ms2t6A modifications contain planar heterocycle moieties that promote cross-strand stacking interactions between A38 of the tRNA and the first base in the mRNA codon to stabilize the codon–anticodon pairing (16).
Transfer RNA modification and infection – Implications for pathogenicity and host responses
2018, Biochimica et Biophysica Acta - Gene Regulatory MechanismsElongator—a tRNA modifying complex that promotes efficient translational decoding
2018, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :Thus, Hrr25 and Sit4 seem to antagonistically control the phosphorylation status of Elongator and its tRNA modification activity [64–66]. Modifications of U34 can modulate and alter the decoding properties of tRNA by their influence on the conformation of the wobble nucleoside and anticodon [3,6,14,71,72,74–76]. The presence of an xm5U derivative at the wobble position was originally proposed to prevent decoding of codons ending with U and C, but more recent structural and genetic studies have suggested that the inability to pair with these codons may not, at least for the tRNAs that contain mcm5s2U, be a consequence of the modified nucleoside [71,72,74,77,78].