Wobble position modified nucleosides evolved to select transfer RNA codon recognition: A modified-wobble hypothesis

doi:10.1016/0300-9084(91)90163-U

Biochimie

Volume 73, Issue 11, November 1991, Pages 1345-1349

https://doi.org/10.1016/0300-9084(91)90163-U Get rights and content

Abstract

While recognized that some wobble exists in the base pairing of the first base of tRNA anticodon with the third of the codon, specific base modifications have evolved to select particular codons. This modified-wobble theory would be exemplified by a single codon recognition imposed on the anticodon by modification of the tRNA wobble position nucleoside.

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For example, the uridine at the wobble position can read the G-ending codon in addition to the A-ending codon. Generally, a modification of wobble nucleoside within tRNA further confers a unique decoding property to anticodon [2–4], and numerous post-transcriptional modifications discovered since then added extra layers of complexity to the original model by Crick [5–9]. In particular, wobble uridines are frequently modified, for example, to 5-carboxymethoxyuridine (cmo5U) or 5-methoxyuridine (mo5U) in Gram-negative or Gram-positive bacteria, respectively.
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Wobble position modified nucleosides evolved to select transfer RNA codon recognition: A modified-wobble hypothesis

Abstract

J Mol Biol

Biochim Biophys Acta

J Mol Biol

J Mol Biol

Biochim Biophys Acta

J Mol Biol

Biochim Biophys Acta

Biochim Biophys Acta

Biochim Biophys Acta

FEBS Lett

J Biol Chem

J Biol Chem

J Mol Biol

Symposia Soc Exp Biol

Science

Cold Spring Harbor Symp Quant Biol

Nucleic Acids Res

Annu Rev Biochem

J Mol Biol

J Biochem

J Mol Evol