In-depth reviewDonor-specific transfusion and donor bone marrow infusion in renal transplantation tolerance: A review of efficacy and mechanisms
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Cited by (70)
Kinetics of mast cell migration during transplantation tolerance
2015, Transplant ImmunologyCitation Excerpt :This reduction was restricted to the presence of HY antigen, as syngeneic controls showed no reduced MC density. Similar to rejection, HY specific tolerance induction requires an active interaction of antigen presenting cells with T-cells [31]. During rejection the presentation of donor antigen by recipient antigen presenting cells leads to T-cell activation, whereas the presentation of the HY antigen to T-cells by donor antigen presenting cells leads to tolerance induction.
Lymphodepletion and homeostatic proliferation: Implications for transplantation
2012, American Journal of TransplantationEndogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation
2010, BloodCitation Excerpt :However, it was later demonstrated that presentation of donor-Ag in the context of self–major histocompatibility complex (MHC) molecules by recipient Ag-presenting cells (APCs), through the indirect pathway of allorecognition, is critical for the DST effect.10-12 The finding that DST sensitizes a percentage of recipients and the introduction of new immunosuppressive agents discontinued the clinical use of DST in the 1980s.7 During the past 15 years, a new generation of cell therapies based on intravenous administration of donor- or recipient-derived dendritic cells (DCs) expanded in vitro and rendered immunosuppressive by pharmacologic or genetic methods has been used to down-regulate the host-versus-graft13-25 and graft-versus-host26 responses.
TRANSPLANT MEDICINE
2008, Pharmacology and Therapeutics: Principles to Practice