Hepatic veno-occlusive disease after bone marrow transplant
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Cited by (57)
Defibrotide Shows Efficacy in the Prevention of Sinusoidal Obstruction Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Study
2022, Transplantation and Cellular TherapyCitation Excerpt :SOS/VOD prophylaxis with defibrotide (Prociclide; Crinos, Como, Italy) 200-400 mg (10-25 mg/kg/d in children weighing less than 30 kg) i.v. in normal saline solution over 2 hours 4 times daily was initiated the day before starting the conditioning regimen and continued until day 20 after transplantation. Patients at higher risk of developing SOS/VOD, such as those with pretransplantation liver disturbance, pretransplantation abdominal irradiation, previous stem cell transplantation [1,31,32] received the higher dosage (400 mg 4 times daily) as compared to standard doses (200 mg 4 times daily) in standard-risk adult patients. In addition, low-dose heparin (5000 IU i.v. continuous/24h if weight <70 kg or 10,000 IU if weight >70 kg) was given routinely [33].
New Ultrasound Techniques Challenge the Diagnosis of Sinusoidal Obstruction Syndrome
2018, Ultrasound in Medicine and BiologyCitation Excerpt :In general, invasive diagnostic measures are not required or justified for the diagnosis of SOS/VOD (Carreras et al. 1993a, 1993b; Mohty et al. 2016), and liver biopsy is seldom performed for the diagnosis of SOS/VOD in the first day after transplantation. On a few occasions, histologic examination of hepatic tissue may be important mainly for differential diagnosis, to avoid underestimation of co-morbidities and false-positive diagnosis (Carreras et al. 1993a, 1993b; Shulman et al. 1995). If a liver biopsy is indicated early post-transplantation, transjugular liver biopsy is the recommended approach rather than percutaneous liver biopsy because with the former procedure, it is possible to perform multiple passes to obtain quality samples, minimizing the risk of complications related to the procedure in general (Kalambokis et al. 2007).
Hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation in adult patients with idiopathic aplastic anemia
2013, Leukemia ResearchCitation Excerpt :In a large study of patients undergoing alloHSCT, the reported incidence of SOS was as high as 53% and the case fatality rate was 47% [1–3]. However, the reported incidence and fatality rates of SOS show high variability, ranging from 0% to 70% [4–6]. Recent reports indicate that the incidence and mortality are decreasing.
Management of hepatic vascular diseases
2012, Journal of HepatologyPediatric Radiation Oncology
2009, Oncology of Infancy and Childhood: Expert Consult - Online and Print