Development of an ovine collagen-based composite biosynthetic vascular prosthesis
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Cited by (19)
Contemporary results with the biosynthetic glutaraldehyde denatured ovine collagen graft (Omniflow II) in femoropopliteal position
2020, Journal of Vascular SurgeryCitation Excerpt :Therefore, besides the currently available synthetic grafts, biologic material may be considered for bypass graft in case of absent autologous vein. The OCP was introduced for clinical use in peripheral bypass almost three decades ago, but there is still a lack of information about its long-term clinical outcome.9-12 Good incorporation of the denatured OCP conduit into the host tissue by deposition of type III and type IV collagen was described.17
Elastomers in vascular tissue engineering
2016, Current Opinion in BiotechnologyCitation Excerpt :Collagen-based cardiac patches derived from bovine pericardium (CardioCel) [35] have allowed for the delivery of mesenchymal stem cells (MSC) in human patients for cardiac repair [36]. The omniflow vascular prosthesis (OVP), created by preimplanting a silicone rod within sheep before removing and stabilizing the deposited collagen has been used as a graft for femoral artery repair and peripheral bypass with around 20,000 implants since 1990 [37]. These outperform ePTFE materials by resisting neointimal hyperplasia, however only limited endothelialization is observed in clinical explants [38].
Tissue-Engineered Vascular Grafts: Autologous Off-the-Shelf Vascular Access?
2012, Seminars in NephrologyCitation Excerpt :A technique to avoid the incubation period, xenogenic tissue could be used, and a xenogenic bioreactor-grown TEVG currently is available outside of the United States. Glutaraldehyde-tanned ovine collagen tubes grown around polyester (Dacron) mesh templates in sheep (Omniflow II; Bio Nova, North Melbourne, Australia) currently have been approved for use in dialysis access in Australia, Germany, and Canada, and are undergoing clinical trials in Europe.35,36 The first version of this product, Omniflow I, had a low patency rate of only 30% at 4 years with occlusive complications, so changes were made to the culture technique and mesh composition.
Animal models for the assessment of novel vascular conduits
2010, Journal of Vascular SurgeryCitation Excerpt :Assessment of the structural durability of tissue-engineered vessels is complicated by fibroblast migration and collagen deposition at the external surface of the vessel, potentially masking graft wall remodeling and weakening that would otherwise lead to aneurysm or rupture. This encapsulation is a feature of ruminants and is also seen in swine, but is more uncommon in primate models.3,123 Implantation of acellular conduit scaffolds for subsequent population through invasion of host tissues represents a promising approach for the development of an off-the-shelf commercial product able to achieve the ideal tissue-engineered autologous arterial graft.177
Structural analysis of a collagen-polyester composite vascular prosthesis
1993, Clinical MaterialsOvine Biosynthetic Grafts for Aortoiliac Reconstructions in Nonsterile Operative Fields
2022, Thoracic and Cardiovascular Surgeon