Elsevier

Vaccine

Volume 10, Issue 3, 1992, Pages 179-184
Vaccine

Paper
The first field trials of the chemically synthesized malaria vaccine SPf66: safety, immunogenicity and protectivity

https://doi.org/10.1016/0264-410X(92)90009-9Get rights and content

Abstract

This paper reports the results of the first field study performed to assess the safety, immunogenicity and protectivity of the synthetic malaria vaccine SPf66 directed against the asexual blood stages of Plasmodium falciparum. Clinical and laboratory tests were performed on all volunteers prior to and after each immunization, demonstrating that no detectable alteration was induced by the immunization process. The vaccinees were grouped as high, intermediate or low responders according to their antibody titres directed against the SPf66 molecule. Two of the 185 (1.08%) SPf66-vaccinated and nine of the 214 (4.20%) placebo-vaccinated volunteers developed P. falciparum malaria. The efficacy of the vaccine was calculated as 82.3% against P. falciparum and 60.6% against Plasmodium vivax.

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