Ancestral haplotypes: conserved population MHC haplotypes
References (28)
- et al.
Haplospecific polymorphism between HLA B and TNF
Hum Immunol
(1992) - et al.
C4 allotyping on plasma or serum: application to routine laboratories
Hum Immunol
(1988) - et al.
Some disease-associated ancestral haplotypes carry a polymorphism of TNF
Hum Immunol
(1989) - et al.
Complotypes extended haplotypes, male segregation distortion and disease markers
Hum Immunol
(1986) - et al.
Studies of haplotypes by pulsed field gel electrophoresis
- et al.
MHC genes and HIV infection
Lancet
(1990) - et al.
Tarsius delta- and beta-globulin genes: conversions, evolution and systematic implications
J Biol Chem
(1989) - et al.
Genetics of leukocyte antigens: a family study of segregation and linkage
Musculoskeletal disease and D-penicillamine: concepts and models
- et al.
Disease associations with complotypes, supratypes and haplotypes
Immunol Rev
(1983)
Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis
J Exp Med
The genomic structure of ancestral haplotypes revealed by pulsed field gel electrophoresis (PFGE)
Endogenous retroviral long terminal repeats within the HLA-DQ locus
Differences in gene copy number carried by different MHC ancestral haplotypes: quantitation after physical separation of haplotypes by pulsed field gel electrophoresis
J Exp Med
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2019, Biology of Blood and Marrow TransplantationCitation Excerpt :Even though these blocks can shuffle and combine to form novel assemblies, some very fixed block combinations exist because of the strong LD [9,13-15]. The block structure and positive LD that occurs in the MHC region enable long stretches of DNA to be inherited as ancestral haplotypes (AHs) [13,16]. Many common MHC haplotypes in whites are either AHs, some ranging from HLA-A up to HLA-DQB1, or recombinants of AHs.
A stochastic epigenetic Mendelian oligogenic disease model for type 1 diabetes
2019, Journal of AutoimmunityCitation Excerpt :For example, MHC CEHs are identified by direct segregation analysis in families and are defined by their HLA-C, -B, complement gene (CFB, C2, C4A, C4B) and HLA-DRB1, -DQB1 markers [59]. These very large (1.4–4.5 Mb) stretches of fixed MHC DNA are essentially identical in many apparently unrelated individuals [60–67]. In European Caucasian populations, about 30 CEHs have a frequency ≥0.5% and account for nearly half of all MHC haplotypes [66].