Elsevier

Neurobiology of Aging

Volume 6, Issue 2, Summer 1985, Pages 131-150
Neurobiology of Aging

Review
Neural transplantation: A review of recent developments and potential applications to the aged brain

https://doi.org/10.1016/0197-4580(85)90031-4Get rights and content

Abstract

—Mammalian neural transplantation has recently been recognized to be a valuable technique for studying normal development and regeneration in the central nervous system. In addition, the ability of grafted neurons to reinnervate damaged regions of the host brain and to ameliorate some neuroendocrine deficits, cognitive disorders and motoric dysfunctions in young adult rodents has suggested that transplantation therapy may be effective in treating human neurodegenerative diseases and neurotransmitter deficiencies related to aging. It is of particular interest that initial studies of neurons transplants in aged rodents indicate that cholinergic, dopaminergic and noradrenergic neurons all integrate to some extent with the aged brain, and that the product of this graft-host interaction is improved behavioral performance of aged subjects. The present paper critically reviews the present domain of neural transplantation, its applications to studies on the properties of the aged mammalian brain and discusses the possible therapeutic use of transplants in ameliorating transmitter-specific abnormalities associated with Parkinson's disease and Alzheimer's disease.

References (157)

  • F.F. Ebner et al.

    The development of peptide-containing neurons within neocortical transplants in adult mice

    Peptides

    (1984)
  • F.H. Gage et al.

    Spatial learning and motor deficits in aged rats

    Neurobiol Aging

    (1984)
  • D.M. Gash et al.

    Transplanted vasopressin neurons and central nervous system effects of vasopressin

  • D.M. Gash et al.

    Cytodifferentiation of the supraoptic nucleus correlated with vasopressin synthesis in the rat

    Brain Res

    (1980)
  • D.M. Gash et al.

    A model system for analyzing functional development of transplanted peptidergic neurons

    Peptides

    (1980)
  • D.M. Gash et al.

    Functional and non-functional transplants: Studies with grafted hypothalamic and preoptic neurons

    Trends Neurosci

    (1984)
  • W.A. Harris

    The eyeless axolotl: Experimental embryogenetics and the development of the nervous system

    Trends Neurosci

    (1983)
  • B. Hoffer et al.

    Electrophysiological and cytological studies of brain homografts in the anterior chamber of the eye: Maturation of cerebellar cortex in oculo

    Brain Res

    (1974)
  • L.L. Iversen et al.

    Loss of pigmented dopamine-γ-hydroxylase pontine cells from locus coeruleus in senile dementia of Alzheimer's type

    Neurosci Lett

    (1983)
  • M. Jacobson et al.

    Selection of appropriate tectal connections by regenerating optic nerve fibers in adult goldfish

    Exp Neurol

    (1965)
  • P. Kubanis et al.

    Age-related behavioral and neurobiological changes: A review with an emphasis on memory

    Behav Neurol Biol

    (1981)
  • E.R. Lewis et al.

    Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. I. Positional and temporal factors

    Brain Res

    (1980)
  • E.R. Lewis et al.

    Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. III. Competitive interactions

    Brain Res

    (1982)
  • E.R. Lewis et al.

    Neurotransmitter characteristics of brain grafts: Striatal and septal tissues form the same laminated input to the hippocampus

    Neuroscience

    (1983)
  • F.M. Longo et al.

    Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers

    Brain Res

    (1983)
  • W.C. Low et al.

    Embryonic neural transplants across a major histocompatibility barrier: Survival and specificity of innervation

    Brain Res

    (1983)
  • J.F. Marshall et al.

    Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational model

    Eur J Pharmacol

    (1977)
  • E.G. McGeer

    Neurotransmitter systems in aging and senile dementia

    Prog Neuropsychopharmacol

    (1981)
  • S.C. McLoon et al.

    Identification of cells in retinal transplants which project to host visual centers: A horseradish peroxidase study in rats

    Brain Res

    (1980)
  • T. Aigner et al.

    Recognition deficit in monkeys following neurotoxic lesions of the basal forebrain

    Soc Neurosci Abstr

    (1984)
  • G.W. Arendash et al.

    Enhancement of sexual behavior in female rats by neonatal transplantation of brain tissue from males

    Science

    (1982)
  • Backlund, E. O., P. O. Grenberg, B. Hamberger, G. Sedvall, Aring;. Seiger and L. Olson. Transplantation of adrenal...
  • C.F. Barker et al.

    Immunologically privileged sites

  • R.T. Bartus et al.

    The cholinergic hypothesis of geriatric memory dysfunction

    Science

    (1982)
  • A. Björklund et al.

    Intracerebral grafting of neuronal cell suspensions VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implants

    Acta Physiol Scand Suppl

    (1983)
  • A. Björklund et al.

    Cholinergic reinnervation of the rat hippocampus by septal implants is stimulated by perforant path lesion

    Brain Res

    (1979)
  • A. Björklund et al.

    Functional reinnervation of the neostriatum in the adult rat by use of intraparenchymal grafting of dissociated cell suspensions from the substantia nigra

    Cell Tissue Res

    (1980)
  • A. Björklund et al.

    Reformation of the several septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons

    Cell Tissue Res

    (1977)
  • A. Björklund et al.

    Cross-species neural grafting in a rat model of Parkinson's disease

    Nature

    (1982)
  • Boer, G. J., D. M. Gash, L. B. Dick and N. Schluter. Vasopressin neurons transplanted into the hypothalamus of neonatal...
  • W. Bondareff et al.

    Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia

    Neurology

    (1982)
  • J.E. Bottenstein

    Differentiated properties of neuronal cell lines

  • M.W. Brightman et al.

    Cerebrospinal fluid compartment as site for neural transplantation

  • R.S. Burns et al.

    The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man

    Can J Neurol Sci

    (1984)
  • B.M. Cattenach et al.

    Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism

    Nature

    (1977)
  • C.W. Cotman et al.

    Trophic influences on the in vivo survival of transplanted cholinergic neurons: A model system for the study of neuron loss in Alzheimer's disease

  • J.T. Coyle et al.

    Alzheimer's Disease: A disorder of cortical cholinergic innervation

    Science

    (1983)
  • K.A. Crutcher et al.

    In vitro evidence for two distinct hippocampal growth factors: Basis of neuronal plasticity

    Science

    (1982)
  • P. Davies

    The neurochemistry of Alzheimer's disease and senile dementia

    Med Res Rev

    (1983)
  • V. DeQuattro et al.

    Anatomy and biochemistry of the sympathetic nervous system

  • Cited by (82)

    • The immunological challenges of cell transplantation for the treatment of Parkinson's disease

      2012, Brain Research Bulletin
      Citation Excerpt :

      These may be novel areas of future research, which we will consider in this paper. Initial studies consisted of autologous adrenal medullary dopaminergic cell transplantation into the striatum [8,40,63,100]. Cell survival of adrenal medullary grafts was problematic in clinical trials [65,66].

    • Microvascular plasticity in aging

      2003, Ageing Research Reviews
    View all citing articles on Scopus
    View full text