Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins
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Cited by (27)
Assessment of neurotoxic effects of tri-cresyl phosphates (TCPs) and cresyl saligenin phosphate (CBDP) using a combination of in vitro techniques
2017, NeuroToxicologyCitation Excerpt :A previous study showed a significant increase in calcium in the sciatic nerve of hens after treatment with the ToCP metabolite CBDP (el-Fawal and Ehrich, 1993). Further studies hypothesized that the influx of calcium and the activation of calcium-dependent kinases are followed by an increase in the phosphorylation levels of cytoskeletal proteins (Lapadula et al., 1992; Suwita et al., 1986). The disturbed intracellular calcium concentration may be linked to other neurotoxic outcomes, such as neurite outgrowth inhibition and neurite degeneration, as well as axon swelling.
Organophosphorus-Induced Delayed Neuropathy
2010, Hayes' Handbook of Pesticide ToxicologyOrganophosphorus-Induced Delayed Neuropathy
2010, Hayes' Handbook of Pesticide Toxicology, Third Edition: Volume 1
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