Original article
A prospective randomized controlled trial of perioperative antibiotic prophylaxis in renal transplantation

https://doi.org/10.1016/0195-6701(88)90089-8Get rights and content

Abstract

We have carried out a prospective, randomized controlled trial of perioperative prophylaxis with cefuroxime and piperacillin in 53 recipients of renal allografts. Twenty-seven patients received antibiotic prophylaxis with three doses of cefuroxime 750 mg and piperacillin 4 g, and 26 patients received no prophylaxis. Risk factors for infection were well matched. Infection rates were analysed for the periods 0–5 days and 0–14 days post-transplant. In the first 5 days, patients receiving antibiotics had fewer infections (3 vs. 11, P = 0·04) but by 14 days this difference was no longer apparent (21 vs. 30, P = NS). There was a total of 15 wound infections, which were more common in the control group both at 5 days (1 vs. 5, P= NS) and at 14 days (4 vs. 11, P = 0·027). Urinary infections were unaffected by prophylaxis. We conclude that perioperative antibiotic prophylaxis results in a modest but worthwhile reduction in the incidence of wound infections after renal transplantation.

References (14)

There are more references available in the full text version of this article.

Cited by (0)

1

JC is supported by the Wellcome Trust.

View full text