Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics

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Abstract

The lymphatic uptake of colloids, whether lipid or non-lipid in nature, is determined by the physiology of the lymphatic system, and the physicochemical characteristics of the colloid in question. The fate of the colloid is also determined by the route of administration, with the subcutaneous route generally considered to be most appropriate for targeting to the regional lymph nodes. With greater understanding of these factors, it will be possible to target the lymph nodes more effectively.

References (82)

  • A. Tumer et al.

    Fate of cholesterol rich liposomes after subcutaneous injection into rats

    Biochim. Biophys. Acta

    (1983)
  • K. Hirano et al.

    Lymphatic transport of liposome-encapsulated agents: effects of liposome size following intraperitoneal administration

    J. Pharm. Sci.

    (1985)
  • P.D. Scholes et al.

    The preparation of sub-200 nm poly(lactide-co-glycolide) microspheres for site specific drug delivery

    J. Control. Release

    (1993)
  • M.P. Osborne et al.

    Radionuclide-labelled liposomes: A new lymph node imaging agent

    Int. J. Nucl. Med. Biol.

    (1979)
  • M.P. Osborne et al.

    Potential application of radionuclide labelled liposomes in the detection of the lymphatic spread of cancer

    Int. J. Nucl. Med. Biol.

    (1982)
  • S. Mangat et al.

    Lymph node localisation of non-specific antibody-coated liposomes

    Life Sci.

    (1985)
  • M.S. Wu et al.

    Modified in vivo behaviour of liposomes containing synthetic glycolipids

    Biochim. Biophys. Acta

    (1981)
  • T.M. Allen et al.

    Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection

    Biochim. Biophys. Acta

    (1993)
  • S.E. Strand et al.

    Radiolabelled colloids and macromolecules in the lymphatic system

    Crit. Rev. Ther. Drug Carrier Syst.

    (1989)
  • W.L. Olszewski

    Peripheral Lymph: Formation and Immune Function

    (1985)
  • J.G. McGeown et al.

    The lymphatic vessels

  • J.R. Casley-Smith

    The fine structure and fucntioning of tissue channels and lymphatics

    Lymphology

    (1980)
  • P.H. Cox

    The kinetics of macromolecule transport in lymph and colloid accumulation in lymph nodes

  • L.V. Leak

    Physiology of the lymphatic system

  • C.C.C. O'Morchoe

    Anatomy of the lymphatic system

  • C. O'Driscoll

    Anatomy and physiology of the lymphatics

  • J.M. Yoffey et al.

    Lymphatics, Lymph and the Lymphomyeloid Complex

    (1970)
  • C.D. Haagensen

    General anatomy of the lymphatic system

  • I. Rusznyak et al.

    Lymphatics and Lymph Circulation

  • H.L. Ioachim

    Lymph Node Biopsy

    (1982)
  • A.G. Stansfeld et al.

    Lymph Node Biopsy Interpretation

    (1992)
  • K. Henry

    Lymph nodes

  • T.S. Leeson et al.

    Lymph organs

  • E.H. Starling

    On the absorption of fluids from the connective tissue spaces

    J. Physiol.

    (1896)
  • C.K. Drinker et al.

    Lymphatics, Lymph and Tissue Fluid

    (1933)
  • L.V. Leak

    The structure of lymphatic capillaries in lymph formation

  • J.R. Casley-Smith

    Mechanisms in the formation of lymph

    Int. Rev. Physiol.

    (1982)
  • C.C. O'Morchoe

    Lymphatic transport pathways during volume expansion

    Microvasc. Res.

    (1980)
  • H.M. Patel

    Serum opsonins and liposomes: Their interaction and opsonophagocytosis

    Crit. Rev. Ther. Drug Carrier Syst.

    (1992)
  • J. Fruhling

    Lymph and lymphatic pathophysiology

  • D.T. O'Hagan et al.

    Particulates and lymphatic drug delivery

  • Cited by (0)

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