Research reportNeuropeptide Y gene expression in PC12 cells and its regulation by nerve growth factor: a model for developmental regulation
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Hypothalamic cell lines to investigate neuroendocrine control mechanisms
2009, Frontiers in NeuroendocrinologyCitation Excerpt :There are excellent reviews on GnRH promoter analysis [19,66,114], and therefore this will not be further covered in this review. However, relatively little has been reported about the regulation of the NPY promoter [7,96,108,109,159], and these studies were only performed in heterologous cell models. It is known from bilateral neural transection experiments and antisense data that the NPY neurons responsible for the reproductive and orexigenic effects of NPY lie within defined regions of the hypothalamus, including the arcuate nucleus [81,133,134], which clearly are not represented by any of the tumor-derived cell lines previously used for NPY studies.
Neuropeptide Y in neural crest-derived tumors: Effect on growth and vascularization
2007, Cancer LettersCitation Excerpt :Moreover, lack of NPY distinguishes central primitive neuroectodermal tumors (cPNET) from their NPY-rich peripheral counterparts (pPNET) belonging to the ESFT [31]. Due to the abundance of NPY and its receptors, tumors of the autonomic nervous system have been widely used to study the regulation of peptide expression, its signaling, and functions of the receptors [32–34]. However, till now, NPY was considered merely a marker of neuronal differentiation and nothing was known about its actual function in these tumors.
Analysis of a repressor region in the human neuropeptide Y gene that binds Oct-1 and Pbx-1 in GT1-7 neurons
2003, Biochemical and Biophysical Research CommunicationsRegulation of chromogranin biosynthesis by neurotrophic growth factors in neuroblastoma cells
2001, Neurochemistry International