The Lake Casitas wild mouse:: Evolving genetic resistance to retroviral disease

doi:10.1016/0168-9525(91)90017-K

Trends in Genetics

Volume 7, Issue 1, January 1991, Pages 22-27

https://doi.org/10.1016/0168-9525(91)90017-K Get rights and content

Abstract

A small colony of feral mice from California continues to flourish in spite of virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.

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Trends in Genetics

ReviewThe Lake Casitas wild mouse:: Evolving genetic resistance to retroviral disease

Abstract

Virology

Virology

Trends Ecol. Evol.

Cell

Virology

Curr. Top. Microbiol. Immunol.

Rev. Infect. Dis.

Cancer Res.

Harvey Lect.

J. Exp. Med.

Jpn. J. Exp. Med.

J. Virol.

J. Virol.

Review
The Lake Casitas wild mouse:: Evolving genetic resistance to retroviral disease