Immune-neuroendocrine interactions
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2008, Seminars in Cancer BiologyCitation Excerpt :Thus, ACTH-induced changes of the immune system activity are not always immunosuppressive, but rather immunomodulatory [67]. It is necessary to take into consideration that immune cells also possess a capacity to produce some hormones, e.g. PRL, GH [78]. Another humoral “effector” of immunity is oxytocin, a hormone synthesized in the hypothalamus and secreted from the pituitary gland.
In vitro substance P-dependent induction of bone marrow cells in common (CD10) acute lymphoblastic leukaemia
2008, Leukemia ResearchCitation Excerpt :First of all, it is antidromally released from sensory nerve endings of C type nerve fibers [3,4] in response to mechanical, chemical, and thermal insults as well as under effect of factors released at sites of tissue injury [4–8]. According to several authors, the presence of peptidergic nerve endings in the closest vicinity of immuno-competent cells in organs most exposed to contact with foreign antigens represents an anatomical exponent of functional links between the mentioned fibers and cells and, more generally, between nervous system and immune system [9–11]. In humans, receptor for SP, known as the neurokinin-1 receptor (NK-1R) can be demonstrated on around 40% peripheral blood lymphocytes [7].
Neural-endocrine-immune complex in the central modulation of tumorigenesis: Facts, assumptions, and hypotheses
2006, Journal of Neuroimmunology
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Wilson Savino is at the Dept of Immunology, Institute Oswaldo Cruz, Rio de Janeiro, Brazil; Mireille Dardenne is at the CNRS URA-1461, Hôpital Necker, F-75743 Paris Cedex 15, France.