T-cell repertoire diversity and clonal expansions in normal and clinical samples
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2023, Journal of Allergy and Clinical ImmunologyAdaptive immune receptor repertoires, an overview of this exciting field
2020, Immunology LettersPerturbation of the T cell receptor repertoire occurs with increasing age in dogs
2018, Developmental and Comparative ImmunologyCitation Excerpt :Although they were selected on the basis of being 'haematologically healthy' it is possible that their disease processes contributed to some of the changes observed in the CDR3 size spectratypes, or that restrictions in their T cell repertoire have influenced their susceptibility to disease. Samples from human clinical patients have been found to have an increased prevalence of CDR3 size spectratypes demonstrating oligoclonal profiles, or polyclonal profiles which contain expanded clones, compared to those from healthy individuals (Pannetier et al., 1995). It is interesting to note that those dogs with the greatest number of skewed CDR3 size spectratypes were diagnosed with cancer, atopic dermatitis and pancreatitis, which evidence from the current literature suggests might be associated with perturbations in the immune system.
Describing the diversity of Ag specific receptors in vertebrates: Contribution of repertoire deep sequencing
2017, Developmental and Comparative ImmunologyCitation Excerpt :In the 90ies, Immunoscope and CDR3-length spectratyping techniques were developed to get global images of TCR/Ig repertoires and their variations upon infections (Pannetier et al., 1993, 1995; Gorski et al., 1994). Spectratyping studies improved the understanding of repertoire structure, allowing the estimation of its heterogeneity and revealing quasi-monoclonal expansion dynamics (Pannetier et al., 1995). Still, the resolution of these techniques remained rather low, providing information about CDR3 length distribution whereas sequence information behind was limited to cloning and sanger sequencing (Arstila et al., 1999, 2000).
Improved analysis of TCRγδ variable region expression in humans
2016, Journal of Immunological Methods
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Christophe Pannetier, Jos Even and Philippe Kourilsky are at the Unité de Biologie Moléculaire du Gène, U.277 INSERM, Insitut Pasteur, 25 rue du Dr Roux. 75724 Paris Cédex 15, France.