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Do B cells drive the diversification of immune responses?

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      This connection has been extensively discussed in a prior review [17]. It has been widely assumed that B cells are important APCs for autoreactive T cells [15,17–20], a concept supported by direct investigations on the potential of autoreactive B cells to activate T cells in vivo and in vitro [21–25]. However, the relative importance of B cell APC function has yet to be determined, and there may be additional roles for B cells, including secretion of cytokines and maintenance of lymphoid architecture (reviewed recently in Ref. [26]).

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    1

    The authors wish to thank their colleagues for discussions of these ideas, and for the provision of data prior to publication as noted in the text. These studies were supported by an Investigator Award of the Arthritis Foundation to M.J.M. and by NIH grants AR-41032 to M.J.M. and AI-26810 to C.A.J.

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