ViewpointDo B cells drive the diversification of immune responses?
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Cited by (175)
Epitope Spreading in Autoimmune Diseases
2015, Infection and AutoimmunityB Cells Producing Pathogenic Autoantibodies
2015, Molecular Biology of B Cells: Second EditionImmune Tolerance Defects in Lupus
2013, Dubois' Lupus Erythematosus and Related Syndromes: Eighth EditionAutoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes
2009, Journal of AutoimmunityCitation Excerpt :Circulating autoantibodies to islet antigens are also strongly associated with development of the disease [2] and in the nonobese diabetic (NOD) mouse model of diabetes, B-cell depletion inhibits the progression to disease [3–5]. Antibody-secreting B-cells may influence autoreactive T-cell responses through their ability to act as highly-efficient antigen-presenting cells, facilitating antigen uptake through the antigen-specific B-cell receptor and modifying antigen processing by forming antibody–antigen complexes that are stable in processing compartments [6–8]. These observations have provoked interest in the autoreactive B-cell as a potential target of immune intervention therapy for Type 1 diabetes [9].
Murine Models of Chronic Graft-versus-Host Disease: Insights and Unresolved Issues
2008, Biology of Blood and Marrow TransplantationCitation Excerpt :Activation of these T cells, in turn, can further promote B cell activation and autoantibody production against a progressively broader range of host-derived epitopes. In this way, the generation of humoral responses against host antigens is continuously perpetuated [34-37]. Another proposed mechanism of SLE progression involves the inability to completely clear apoptotic cells following GVHR from secondary immune organs, thus providing an additional source of autoantigens and further driving autoantibody production [38].
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors
2007, Seminars in ImmunologyCitation Excerpt :This connection has been extensively discussed in a prior review [17]. It has been widely assumed that B cells are important APCs for autoreactive T cells [15,17–20], a concept supported by direct investigations on the potential of autoreactive B cells to activate T cells in vivo and in vitro [21–25]. However, the relative importance of B cell APC function has yet to be determined, and there may be additional roles for B cells, including secretion of cytokines and maintenance of lymphoid architecture (reviewed recently in Ref. [26]).
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The authors wish to thank their colleagues for discussions of these ideas, and for the provision of data prior to publication as noted in the text. These studies were supported by an Investigator Award of the Arthritis Foundation to M.J.M. and by NIH grants AR-41032 to M.J.M. and AI-26810 to C.A.J.