review
Role of heparan sulfate in immune system-blood vessel interactions☆

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Abstract

Heparan sulfate proteoglycan, a component of endothelial cell membranes and extracellular matrices, is involved in a number of the critical functions of endothelium and of antigen-presenting cells. This review discusses how heparan sulfate is released from endothelial cells during inflammation, how to loss of heparan sulfate potentially alters endothelial cell physiology, and how the presence of heparan sulfate in a soluble form might regulate the functioning of lymphocytes at sites of inflammation.

References (53)

  • J.A. Marcum et al.
  • C.F. Reilly et al.

    J. Biol. Chem.

    (1989)
  • T. Kojima et al.

    J. Biol. Chem.

    (1992)
  • G. Mertens et al.

    J. Biol. Chem.

    (1992)
  • A.D. Murdoch et al.

    J. Biol. Chem.

    (1992)
  • S.H. Murch et al.

    Lancet

    (1993)
  • M. Ishihara et al.

    J. Biol. Chem.

    (1987)
  • M. Nakajima et al.

    J. Biol. Chem.

    (1991)
  • T. Kojima et al.

    J. Biol. Chem.

    (1992)
  • J.H. Lawson et al.

    J. Biol. Chem.

    (1993)
  • Y. Tanaka et al.

    Immunol. Today

    (1993)
  • J.L. Platt et al.

    Dev. Biol.

    (1990)
  • U. Saxena et al.

    J. Biol. Chem.

    (1990)
  • U. Saxena et al.

    J. Biol. Chem.

    (1991)
  • G.M. Oosta et al.

    J. Biol. Chem.

    (1982)
  • P. Bashkin et al.

    Blood

    (1990)
  • E. Ruoslahti

    Annu. Rev. Cell Biol.

    (1981)
  • M. Bernfield et al.

    Annu. Rev. Cell Biol.

    (1992)
  • N.S. Key et al.

    Arterio. Thromb.

    (1992)
  • L.E. Wrenshall et al.

    J. Immunol.

    (1991)
  • L. Kjellen et al.

    Annu. Rev. Biochem.

    (1991)
  • A.E. Postlethwaite et al.
  • M.G. Kinsella et al.

    J. Cell Biol.

    (1986)
  • D.E. Humpheries et al.

    J. Cell. Physiol.

    (1986)
  • N. Savion et al.

    J. Cell. Physiol.

    (1984)
  • Y. Naparstek et al.

    Nature

    (1984)

    • Cited by (0)

    ☆

    This work was supported in part by a grant from the National Institutes of Health (HL46810).

    ∗

    Jeffrey L. Platt is an Established Investigator of the American Heart Association.

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