Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review
References (72)
- et al.
Effects of idebenone and related compounds on respiratory activities of brain mitochondria, and on lipid peroxidation of their membranes
Arch. Gerontol. Geriatr.
(1989) - et al.
Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia
Jpn. J. Pharmacol.
(1984) - et al.
Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia
Arch. Gerontol. Geriatr.
(1989) - et al.
Effects of idebenone on monamine metabolites in cerebrospinal fluid of patients with cerebrovascular dementia
Arch. Gerontol. Geriatr.
(1989) - et al.
Effects of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolization
Jpn. J. Pharmacol.
(1985) - et al.
Cerebral embolization leads to memory impairment of several learning tasks in rats
Pharmacol. Biochem. Behav.
(1986) - et al.
Protective effect of idebenone against hypoxia in mice
Arch. Gerontol. Geriatr.
(1989) - et al.
In vivo electrochemical detection of 5-hydroxyindoles in the dorsal hippocampus of anesthetized rats treated with idebenone (CV-2619)
Jpn. J. Pharmacol.
(1985) - et al.
Brain distribution of idebenone and its effect on local cerebral glucose utilization in rats
Arch. Gerontol. Geriatr.
(1989) - et al.
Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats
Arch. Gerontol. Geriatr.
(1989)
Inhibitory effect of idebenone (CV-2619), a novel compound, on vascular leasions in hypertensive rats
Jpn. J. Pharmacol.
Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia
Arch. Gerontol. Geriatr.
Effects of idebenone on neurological deficits following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats
Arch. Gerontol. Geriatr.
Effects of idebenone on electroencephalograms of patients with cerebrovascular disorders
Arch. Gerontol. Geriatr.
Effects of idebenone (CV-2619) on the metabolism of monoamines especially serotonin, in the brain of normal rats and rats with cerebral ischemia
Jpn. J. Pharmacol.
Stimulation of the respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV-2619), a new agent improving cerebral metabolism
FEBS Lett.
Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619)
Jpn. J. Pharmacol.
Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619) in brain mitochondria and mode of action of the inhibition
Biochem. Biophys. Res. Commun.
Inhibition of lipid peroxidation by idebenone in brain mitochondria in the presence of succinate
Arch. Gerontol. Geriatr.
Inhibition of brain mitochondrial swelling by idebenone
Arch. Gerontol. Geriatr.
Effects of idebenone on lipid peroxidation and hemolysis in erythrocytes of stroke-prone spontaneously hypertensive rats
Arch. Gerontol. Geriatr.
Inhibition of platelet aggregation by idebenone and the mechanism of the inhibition
Arch. Gerontol. Geriatr.
Simultaneous determination of reduced and oxidized ubiquinones
Methods Enzymol.
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats
Jpn. J. Pharmacol.
Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats
Arch. Gerontol. Geriatr.
Idebenone improves learning and memory impairment induced by cholinergic or serotonergic dysfunction in rats
Arch. Gerontol. Geriatr.
Immunogenicity studies on idebenone (CV-2619)
Jpn. Pharmacol. Ther.
Acute toxicity study of idebenone (CV-2619) in mice and rats
Jpn. Pharmacol. Ther.
A double-blind study of the efficacy of Idebenone in the treatment of patients with cognitive deficit due to cerebrovascular disease
Acta Gerontol. (Pavia)
Efficacy and safety CV-2619 tablets in long-term clinical treatment of elderly cerebral arteriosclerotic patients
Rinsho Iyaku
Effects of idebenone (CV-2619) on fertility and general reproductive performance in the rat
Jpn. Pharmacol. Ther.
Effects of idebenone (CV-2619) on peri- and post-natal development in the rat
Jpn. Pharmacol. Ther.
Teratogenic effects of idebenone (CV-2619) in the rat
Jpn. Pharmacol. Ther.
Teratogenic effects of idebenone (CV-2619) in the rabbit
Jpn. Pharmacol. Ther.
Changes of behavior, cerebral blood flow and metabolism after bilateral carotid occlusion in stroke-prone SHR, Stroke-resistant SHR and normal Wistar-Kyoto rats
Jpn. Heart J.
Combination effects of Idebenone and Vinpocetine on N2-induced hypoxia and CO2-induced amnesia in mice
Jpn. Pharmacol. Ther.
Cited by (78)
Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors
2019, Bioorganic ChemistryCitation Excerpt :There are many approved drugs or diet supplement containing the quinone scaffold, such as Idebenone and coenzyme Q10 (CoQ10). Idebenone and CoQ10 share the same p-quinone headgroup (CoQ0) and both of them are treated as a drug or dietary supplement in many countries [36–43]. CoQ10 is a main homologue of CoQ existing in humans, and Idebenone, a synthetic quinone with similarities to coenzyme-Q1, had been introduced to the market in 1986 under the name Avan in Japan [36–43].
Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition
2018, Pharmacological ResearchCitation Excerpt :Idebenone is approved in Europe for treatment of visual impairment due to Leber's hereditary Optic Neuropathy, LHON [76–85], and has been considered for Duchenne's Muscular Dystrophy, DMD [86–89]. It is possible that idebenone's efficacy in LHON and DMD may be supported by the Shc mechanism rather than or in addition to its mitochondrial mechanisms previously described, especially as idebenone engages the Shc target at the 100 nM plasma concentrations reached by idebenone in human patients [64–66]. HTS for metabolic insulin sensitizers, validation of compounds, mitochondrial IC50 determination, EC50 of insulin sensitization, identification of idebenone as a Shc inhibitor/insulin sensitizer – Tomilov; Affinity of 30 identified compounds to Shc protein Allen; IC50 of Shc-NPEYp interaction for 7 identified compounds, establishment of NPEYp binding assays and Shc – Chun Kiu; Blinded measurement of insulin sensitivity in vivo – Bettaieb; overseeing entire project – Cortopassi.
Cellular interactions and photoprotective effects of idebenone-loaded nanostructured lipid carriers stabilized using PEG-free surfactant
2015, International Journal of PharmaceuticsCitation Excerpt :It is well known that excessive production of ROS or reduction in the endogenous antioxidants to neutralize them results in oxidative stress which in turn causes damage to intracellular lipids, proteins and DNA (Linder, 2010). IDB, a key cell membrane antioxidant and essential constituent of electron transport chain (ETC) in mitochondria, acts by inhibiting the lipid peroxidation and thus protects cell membrane and mitochondria membrane integrity from oxidative stress (Suno and Nagaoka, 1984; Zs-Nagy, 1990). Regarding the placebo-NLCs + UVB (Fig. 10A), it is seen that it exhibited significantly lower MFI, when compared to positive control cells (p < 0.001), indicating the placebo-NLCs under UVB irradiation provided photoprotection but they in spite of that compromised over 3-fold increase in ROS production, when compared to IDB–NLCs + UVB, indicating loading of IDB in NLCs system boosted HaCaT cell’s protection against oxidative stress.
Evolution of cytochrome bc complexes: From membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates
2013, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :Propofol treatment had strong dose-dependent protection attenuating alteration of these parameters [204]. An ubiquinone analog idebenone (6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone) has been shown to protect the mitochondrial membrane against lipid peroxidation and improve the overall brain function after vascular disorders due to strokes or experimental cerebral ischemia [205–208]. Another ubiquinol analog, decylubiquinol, also blocked ROS production and prevented activation of the mitochondrial permeability transition and the cell death [209].