Molecular characterization of a Dirofilaria immitis cDNA encoding a highly immunoreactive antigen
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Cited by (39)
Molecular cloning and characterization of a nematode polyprotein antigen/allergen from the human and animal hookworm Ancylostoma ceylanicum
2014, Molecular and Biochemical ParasitologyCitation Excerpt :However, the individual subunits have an α-helix rich structure, making them structurally different from the lipid transporters found in vertebrates. These smaller subunits are processed and secreted from worms into the host and surrounding environment [26–31]. Due to the requirement of exogenous fatty acids by the parasites, host fatty acid levels may influence pathogenesis of disease caused by parasitic nematodes.
Ascaris - Antigens, Allergens, Immunogenetics, Protein Structures
2013, Ascaris: The Neglected ParasiteThe complexity of the secreted NPA and FAR lipid-binding protein families of Haemonchus contortus revealed by an iterative proteomics-bioinformatics approach
2009, Molecular and Biochemical ParasitologyThe nematode polyprotein allergens/antigens
2000, Parasitology TodayCitation Excerpt :NPAs appear to be secreted by several species of ascarid, although not by the larvae of T. canis23,24. NPAs are less prominent as somatic components in other groups of nematodes, but they have attracted attention as the surface-proximal and secreted ‘ladder’ proteins of filarial nematodes, originally revealed by radiolabelling the surface of living Brugia and Dirofilaria worms25–29. Immunoelectronmicroscopy in Brugia has indicated that its NPA (gp15/400) is present in the matrix of the basal laminae separating the hypodermal cord and the somatic musculature, between individual muscle blocks, in the basal lamina surrounding the oesophagus and at low levels within cells.
The polyprotein lipid binding proteins of nematodes
2000, Biochimica et Biophysica Acta - Protein Structure and Molecular EnzymologyCarboxy-terminal sequence divergence and processing of the polyprotein antigen from Dirofilaria immitis
1996, Molecular and Biochemical Parasitology
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Present address: Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA
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Present address: Department of Molecular and Cell Biology, University of California, Berkeley, CA
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Department of Infectious Disease, Roche Molecular Systems, Emeryville, CA; USA.