Original articlep53 gene mutations with chromosome 17 abnormalities in chronic myelogenous leukemia blast crisis patients persist in long term cell lines but may be acquired in acute myeloid leukemia cells in vitro☆
References (25)
- et al.
Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia
Blood
(1990) - et al.
Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia
Blood
(1989) - et al.
Mutation of the p53 gene in human acute myelogenous leukemia
Blood
(1991) - et al.
p53 gene mutations in myeloid leukemia with 17p monosomy
Blood
(1991) - et al.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines
Blood
(1992) - et al.
Ph positive chronic myeloid leukemia with near haploid conversion in vivo and establishment of a continu ously growing cell line with similar cytogenetic pattern
Cancer Genet Cytogenet
(1987) - et al.
Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
Genomics
(1989) - et al.
Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis
Blood
(1991) - et al.
Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
Cell
(1992) Tumor suppressor genes
Science
(1991)
Expression of wild type p53 is not compatible with continued growth of p53 negative tumor cells
Mol Cell Biol
(1991)
Mutations in the p53 gene occur in diverse human tumor types
Nature
(1989)
Cited by (6)
Astrocytoma derived short-term cell cultures retain molecular signatures characteristic of the tumour in situ
2009, Experimental Cell ResearchEstablishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene
2006, Cancer Genetics and CytogeneticsCitation Excerpt :For example, leukemia cells removed from their environment (e.g., bone marrow [BM]) usually undergo apoptosis within a few weeks even if cultured carefully. Moreover, during the process of establishing cell lines, a variety of events may intrude, singly or in combination: a small population of leukemia cells may be selected, transcriptional control may change, or genomic alterations may be accumulated [2,3]. A new culture system is needed, one that is more similar to the native environment.
Characterization of the mutational profile of 11 diffuse large B-cell lymphoma cell lines
2018, Leukemia and LymphomaThe p53 orbit in chronic myeloid leukemia: Time to move to patient care
2016, Translational Cancer ResearchVariation in RNA expression and genomic DNA content acquired during cell culture
2004, British Journal of Cancer
- ☆
This work was supported by NIH Grant RR5511 and ACS Grant DHP 101 to S.S. and by a grant from the Adler Foundation in New York, NY to B.S.A.
Copyright © 1995 Published by Elsevier Inc.