Lack of specificity of reduced platelet imipramine binding in different psychiatric conditions

doi:10.1016/0165-1781(89)90168-6

Psychiatry Research

Volume 30, Issue 1, October 1989, Pages 21-29

https://doi.org/10.1016/0165-1781(89)90168-6 Get rights and content

Abstract

We compared ³H-imipramine binding in 10 major depressives with that in 29 healthy volunteers, 13 patients with panic disorder, 9 patients with bulimia, 9 suicide attempters, and 6 schizophrenic patients. None of the comparison groups had histories of major mood disorders, except the suicide attempters. We found a significant reduction of the maximum binding capacity (B_max) in all groups of patients as compared with healthy controls. These data cast doubt upon the specificity of the decrease of platelet ³H-imipramine binding in major depression, but suggest a possible pharmacological common denominator involving the serotonin system.

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^∗: Donatella Marazziti, M.D., Ph.D., is now attending the specialty school in Applied Biochemistry at the University of Pisa, Italy. Gian Franco Placidi, M.D., is Associate Professor of Psychogeriatics, and Giovanni Battista Cassano, M.D., is Professor of Psychiatry and Chief of the 2nd Chair of Psychiatric Clinic, Department of Psychiatry, University of Pisa, Italy. Hagop S. Akiskal, M.D., is Professor of Psychiatry and Associate Professor of Pharmacology at the University of Tennessee, Memphis, where he is also Director of the Section of Affective Disorders.

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