Phenotypic heterogeneity and recycling capacity of natural killer cells in normal human pregnancy
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Functional prominence of natural killer cells and natural killer T cells in pregnancy and infertility: A comprehensive review and update
2022, Pathology Research and PracticeCitation Excerpt :They concluded that miR-30e is involved in creating an immune tolerance periphery in the maternal-fetal interface [32]. In a normal human gestation, the lytic activity of NK cells and the number of CD16− NK cells in the peripheral blood are reduced compared to non-pregnant individuals [56,57]. It has also been observed that, in these cells, the expression of the inhibitory KIR receptor (CD94/NKG2A) increases in the primary weeks of pregnancy and reaches a maximum by the third month, and then decreases to baseline [58].
Recent insights into the impact of immune dysfunction on reproduction in autoimmune thyroiditis
2021, Clinical ImmunologyCitation Excerpt :The other 10% are CD56brightCD16−NK cells, which have immunoregulatory functions [84]. During normal pregnancy, which is regulated by hormones, the number and dissolution activity of CD56dimCD16+NK cells decrease [85,86], while the expression of inhibitory receptors increases [87]. NK cells dysregulation in the peripheral blood is closely related to reproductive failures, including RM and infertility [88].
Pregnancy as a model for aging
2020, Ageing Research ReviewsCitation Excerpt :During uncomplicated pregnancy, NK phenotype and quantity fluctuate greatly. Peripheral blood NK quantity decreases due to a reduction in the CD16+ (Gregory et al., 1985; Beer et al., 1996), and the cells exhibit decreased lytic activity (Gregory et al., 1987). There is also a fluctuation of inhibitory receptors among peripheral T cells and NK cells in early pregnancy, peaking in the third month and declining postpartum (Ponte et al., 1999).
Immunology of pregnancy: towards a unifying hypothesis
1992, European Journal of Obstetrics and Gynecology and Reproductive BiologyNatural killer cell activity from pregnant subjects is modulated by RU 486
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