Specific histamine release capacity of peptides selected from the modelized der P I protein, a major allergen of Dermatophagoides pteronyssinus
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Cited by (28)
In silico prediction of B-cell epitopes for twenty-five mite allergens: The therapeutic potentials for immunotherapy
2019, Molecular and Cellular ProbesCitation Excerpt :In our study, it was shown that D57, L58 and E92 residues are also part of epitopes. Jeannin et al. [42] have mentioned in their study that 118CQIYPPNVNKIREALAQ133 sequences might correspond to B-cell epitopes of Der p 1 which partially overlaps with the predicted epitope in our study (Y121–N126). They have also reported 188VRNSWTNWGDNGY201 as Der p 1 epitope.
Suppression of allergen-specific B lymphocytes by chimeric protein-engineered antibodies
2014, ImmunobiologyCitation Excerpt :One of the major allergenic molecules of Dpt is the glycoprotein Der p 1, and some potential epitopes have been predicted by bioinformatic methods. Using a three-dimensional model, Der p 1 (222-amino acids based protein) has been mapped, four potential B cell epitopes have been selected and their IgE-dependent biological activities demonstrated (Greene and Thomas 1992; Jeannin et al. 1992; Duez et al. 2001). One of these epitopes (peptide p52-71) was used as a model epitope in the present study.
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen
2006, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Located 14 Å from the catalytic site, Mg++ is unlikely to play a major role, if any, in Der p 1 activity, as confirmed by maintenance of peptidolytic activity in presence of EDTA (data not shown), but its location close to the allergen surface could alter or stabilize the conformation of IgE epitopes, including the 52-56 stretch (Fig 3, D). Such epitopes have been described.10 Interestingly, in the Der p 1.0110 isoform, Glu 44 is replaced by an Asp (see this article's Table E2 in the Online Repository at www.jacionline.org).
Molecular biology of allergens
1996, Immunology and Allergy Clinics of North America