The role of transforming growth factor-beta in hematopoiesis. A review

doi:10.1016/0145-2126(91)90118-D

Leukemia Research

Volume 15, Issue 4, 1991, Pages 179-184

https://doi.org/10.1016/0145-2126(91)90118-D Get rights and content

Abstract

The role of TGF_β hematopoiesis is currently being defined. It does appear that TGF_β and related polypeptides [34–36] can modulate and regulate bone marrow and thymic-derived cells throughout their functional life span. The effects of TGF_β are pleiotropic and may depend on (a) cell lineage, (b) specific cellular phenotype, (c) stage of differentiation, (d) immediate microenvironment, (e) other cytokines and (f) cellular function. The understanding of TGF_β and its relationship to other cytokines should not only increase our understanding of hematopoiesis but may also have therapeutic implications.

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ReviewThe role of transforming growth factor-beta in hematopoiesis. A review

Abstract

Cell

J. biol. Chem.

Cell

J. biol. Chem.

J. Cell Biochem.

Blood

Cell Immun.

Biochem. biophys. Res. Commun.

Blood

Cell

Transforming growth factor-β: biological function and chemical structure

Science

Some recent advances in the chemistry and biology of transforming growth factor-beta

J. Cell Biol.

Transforming growth factors in nonneoplastic tissues and their role in controlling cell growth

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factorβ:aproposedmodel for indirect mitogenesis involving autocrine activity

Modulation of cytokine production by transforming growth factor-β-

J. Immun.

Heterodimeric transforming growth factor β

Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells

Science

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

Nature

Review
The role of transforming growth factor-beta in hematopoiesis. A review