PaperMeniscal replacement using a porous polymer prosthesis: a preliminary study in the dog
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Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication
2021, Journal of Colloid and Interface ScienceCitation Excerpt :From the results of AFM, XPS and water contact angle, we can infer the HADN and Glu successfully coated the PCU surface. PCU is a popular biomaterial for porous and nonporous permanent meniscus implants for the replacement of damaged meniscus [47–51]. However, its lubrication properties during the swing phase have been shown to be suboptimal [4] and need improvement.
An in vitro study of cartilage–meniscus tribology to understand the changes caused by a meniscus implant
2017, Colloids and Surfaces B: BiointerfacesDevelopment of meniscus substitutes using a mixture of biocompatible polymers and extra cellular matrix components by electrospinning
2016, Materials Science and Engineering CToward scaffold-based meniscus repair: Effect of human serum, hyaluronic acid and TGF-ß3 on cell recruitment and re-differentiation
2013, Osteoarthritis and CartilageCitation Excerpt :Synthetic polymers seem to be beneficial because of the controllability of porosity, degradation rate, 3D-structure and mechanical properties. In preclinical studies, they were shown to lead to less degenerative changes of the adjacent articular cartilage compared to meniscectomy but without clinical prove in the majority of cases14–16. Based on the long-term clinical experience with resorbable polyglycolic acid (PGA) or polylactic-co-glycolic acid (PLGA) scaffolds in the field of cell-based17 and cell-free cartilage repair18–20, first in vitro studies for scaffold-based meniscus repair were recently performed21.
Elastomeric biomaterials for tissue engineering
2013, Progress in Polymer ScienceCitation Excerpt :This might be useful for tissues with slower healing and remodelling times, or with an inability to maintain innate structural integrity (e.g., large wounds). In addition to cardiovascular tissue engineering, PUs have proven highly versatile for the repair of other tissue types including nerves [92,152–155], blood vessels [147] and load-bearing tissue including bone [128,129,156,157], cartilage [158], fibrocartilage [159–164] and ligament [120,127], as summarized in Table 9. From the terminology point of view, a polyhydroxyalkanoate (PHA) is the polymer formed from a hydroxyl-alkanoic acid (i.e., carboxylic cid) which can be defined as any acid with the structure HORCOOH, where R is an alkyl unit having the composition of CnH2n.
Expanded human meniscus-derived cells in 3-D polymer-hyaluronan scaffolds for meniscus repair
2012, Acta BiomaterialiaCitation Excerpt :Synthetic polymers are advanced because of the controllability of porosity, degradation rate, three-dimensional structure and mechanical properties. Preclinical studies using polylactic acid (PLA) [26], polycaprolactone [27], polyurethane [28,29], polyvinyl alcohol [29–31] and its derivates and copolymers for meniscus replacement showed less degenerative changes of the articular cartilage compared to a meniscectomy control group. However, most of these studies were not clinically proven.