Elsevier

Biomaterials

Volume 17, Issue 12, June 1996, Pages 1169-1175
Biomaterials

Paper
Meniscal replacement using a porous polymer prosthesis: a preliminary study in the dog

https://doi.org/10.1016/0142-9612(96)84937-4Get rights and content

Abstract

A porous polyurethane prosthesis was used to replace the lateral meniscus in the dog. After an initial ingrowth of fibrous tissue, the prostheses became filled with tissue strongly resembling normal meniscal fibrocartilage. Although less severe than seen after total meniscectomy, cartilage degeneration was frequent, possibly because tissue ingrowth in the prostheses occurred too slowly. Porous polymers can be useful for replacement of the meniscus, provided that chemical and physical properties are optimized.

References (43)

  • T.J. Fairbank

    Knee joint changes after meniscectomy

    J Bone Joint Surg

    (1948)
  • J.P. Jackson

    Degenerative changes in the knee after meniscectomy

    Br Med J

    (1968)
  • R.C. Medlar et al.

    Meniscectomies in children. Report of long-term results (mean 8.3 years) of 26 children

    Am J Sports Med

    (1980)
  • E.M. Tapper et al.

    Late results after meniscectomy

    J Bone Joint Surg

    (1969)
  • J.B. McGinty et al.

    Partial or total meniscectomy. A comparative analysis

    J Bone Joint Surg

    (1977)
  • M.D. Northmore-Ball et al.

    Arthroscopic open partial and total meniscectomy. A comparative study

    J Bone Joint Surg

    (1983)
  • S.P. Arnoczky et al.

    Microvasculature of the human meniscus

    Am J Sports Med

    (1982)
  • R.E. Cassidy et al.

    Repair of peripheral meniscus tears: a preliminary report

    Am J Sports Med

    (1981)
  • K.E. DeHaven

    Decision-making factors in the treatment of meniscus lesions

    Clin Orthop

    (1990)
  • P. Hamberg et al.

    Suture of new and old peripheral meniscus tears

    J Bone Joint Surg

    (1983)
  • S.P. Arnoczky et al.

    Meniscal repair using an exogenous fibrin clot: an experimental study in dogs

    J Bone Joint Surg

    (1988)
  • Cited by (64)

    • Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication

      2021, Journal of Colloid and Interface Science
      Citation Excerpt :

      From the results of AFM, XPS and water contact angle, we can infer the HADN and Glu successfully coated the PCU surface. PCU is a popular biomaterial for porous and nonporous permanent meniscus implants for the replacement of damaged meniscus [47–51]. However, its lubrication properties during the swing phase have been shown to be suboptimal [4] and need improvement.

    • Toward scaffold-based meniscus repair: Effect of human serum, hyaluronic acid and TGF-ß3 on cell recruitment and re-differentiation

      2013, Osteoarthritis and Cartilage
      Citation Excerpt :

      Synthetic polymers seem to be beneficial because of the controllability of porosity, degradation rate, 3D-structure and mechanical properties. In preclinical studies, they were shown to lead to less degenerative changes of the adjacent articular cartilage compared to meniscectomy but without clinical prove in the majority of cases14–16. Based on the long-term clinical experience with resorbable polyglycolic acid (PGA) or polylactic-co-glycolic acid (PLGA) scaffolds in the field of cell-based17 and cell-free cartilage repair18–20, first in vitro studies for scaffold-based meniscus repair were recently performed21.

    • Elastomeric biomaterials for tissue engineering

      2013, Progress in Polymer Science
      Citation Excerpt :

      This might be useful for tissues with slower healing and remodelling times, or with an inability to maintain innate structural integrity (e.g., large wounds). In addition to cardiovascular tissue engineering, PUs have proven highly versatile for the repair of other tissue types including nerves [92,152–155], blood vessels [147] and load-bearing tissue including bone [128,129,156,157], cartilage [158], fibrocartilage [159–164] and ligament [120,127], as summarized in Table 9. From the terminology point of view, a polyhydroxyalkanoate (PHA) is the polymer formed from a hydroxyl-alkanoic acid (i.e., carboxylic cid) which can be defined as any acid with the structure HORCOOH, where R is an alkyl unit having the composition of CnH2n.

    • Expanded human meniscus-derived cells in 3-D polymer-hyaluronan scaffolds for meniscus repair

      2012, Acta Biomaterialia
      Citation Excerpt :

      Synthetic polymers are advanced because of the controllability of porosity, degradation rate, three-dimensional structure and mechanical properties. Preclinical studies using polylactic acid (PLA) [26], polycaprolactone [27], polyurethane [28,29], polyvinyl alcohol [29–31] and its derivates and copolymers for meniscus replacement showed less degenerative changes of the articular cartilage compared to a meniscectomy control group. However, most of these studies were not clinically proven.

    View all citing articles on Scopus
    View full text