Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients

doi:10.1016/0140-6736(90)90998-K

The Lancet

Volume 335, Issue 8695, 21 April 1990, Pages 936-938

https://doi.org/10.1016/0140-6736(90)90998-K Get rights and content

Abstract

In a double-blind randomised trial an infusion of doxapram, 2 mg per min for 6 h immediately after surgery and repeated on the first postoperative day, or the same volume of saline, was given to 39 patients who underwent upper abdominal surgery and who were at high risk of postoperative pulmonary complications. The patients were assessed pre-operatively and during the first 5 postoperative days by physical examination, spirometry, blood-gas analysis, and chest radiography. Postoperative pulmonary complications were defined as temperature over 38°C for 2 days, abnormal auscultation, pathological radiograph, and/or productive cough. Data from 16 patients per group were analysed. Significantly more patients in the placebo group had three criteria of postoperative pulmonary complication compared with the doxapram group (63% vs 19%). The doxapram group also had higher PaO₂ postoperatively.

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MEDICAL SCIENCEEffect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients

Abstract

Am J Med

Br J Anaesth

Br J Anæsth

Surg Clin North Am

Pulmonary pathophysiology in surgical patients

Surg Clin North Am

Post-operative analgesia combined with doxapram

Anaesthesia

Role of doxapram in reducing pulmonary complications after major surgery

Br Med J

Nye Ho̸yde-vekt-tabeller for norske kvinner og menn

MEDICAL SCIENCE
Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients

Nye H $o ̸$ yde-vekt-tabeller for norske kvinner og menn