Elsevier

The Lancet

Volume 335, Issue 8686, 17 February 1990, Pages 396-397
The Lancet

CLINICAL PRACTICE
Control of house dust mite antigen in bedding

https://doi.org/10.1016/0140-6736(90)90219-UGet rights and content

Abstract

Bedding has been constructed with a vapour-permeable waterproof fabric that is impermeable to house dust mite antigen (Der p1). Der p1 levels per gram of mattress dust after 12 weeks' use of the new covering were 1% of levels in control samples from mattresses cleaned conventionally.

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    These covers are available by mail or in retail stores and are breathable, comfortable, and nearly 100% exclusive.6 More than a dozen clinical trials of allergen-proof encasings have been published that were at least 3 months long and reported mite allergen levels in bedding.7-21 All of these trials report reduced allergen concentrations, but the degree of allergen reduction varied widely, from 39% to 99.9% (median, 89%), as did the final allergen concentrations achieved (range, 0.01-8.50 μg/g; median, 0.77 μg/g).

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    Furthermore, no significant differences between the active and placebo groups were seen for PEF variability. The effectiveness of HDM-impermeable covers for reducing HDM allergen exposure has also been suggested by other studies.4-15 Measures that lead to very large reductions in HDM allergen exposure, such as HDM-impermeable covers, can have beneficial effects in patients with HDM allergy with asthma.

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