Cell
Volume 61, Issue 3, 4 May 1990, Pages 535-547
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Article
The roles of Drosophila cyclins A and B in mitotic control

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Abstract

We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle.

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    Present address: Friedrich-Miescher-Laboratorium der Max-Planck-Gesellschaft, D-7400 Tübingen, Federal Republic of Germany.

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