Cell
Volume 63, Issue 4, 16 November 1990, Pages 707-716
ArticleMHC class II-associated invariant chain contains a sorting signal for endosomal compartments
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Cited by (555)
Functional Specialization of Dendritic Cell Subsets
2022, Encyclopedia of Cell Biology: Volume 1-6, Second EditionInvariant chain p41 mediates production of soluble MHC class II molecules
2019, Biochemical and Biophysical Research CommunicationsCitation Excerpt :A recent study using mice that lack specific promoter regions of the CIITA gene showed that sMHC II molecules are mainly released from dendritic cells and macrophages but not from B cells [12]. Ii is essential in antigen presentation by transporting MHC II molecules to the endosomal/lysosomal compartment [14,15]. Moreover, Ii p41, but not the p31 isoform, associates with cathepsin L to stabilize their mature form and protects cathepsin L from degradation by other proteases [30,31].
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