Cell
ArticleIdentification of sequences in a yeast histone promoter involved in periodic transcription
References (34)
- et al.
Specific DNA binding of GAL4, a positive regulatory protein of yeast
Cell
(1985) Yeast promoters: positive and negative elements
Cell
(1984)- et al.
Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site
Cell
(1983) - et al.
Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae
Cell
(1984) - et al.
Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis
J. Mol. Biol.
(1974) - et al.
Isolation of yeast histone genes H2A and H2B
Cell
(1979) - et al.
Cell-cycle regulation of yeast histone mRNA
Cell
(1981) - et al.
Periodic transcription of yeast histone genes
Cell
(1982) - et al.
GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast
Cell
(1985) - et al.
A repressor (MAT|ga2 product) and its operator control expression of a set of cell type specific genes in yeast
Cell
(1985)
A repetitive DNA sequence that confers cell-cycle START (CDC28)-dependent transcription of the HO gene in yeast
Cell
Transcription and regulatory signals at the mating type locus in yeast
Cell
DNA sequences of yeast H3 and H4 histone genes from two nonallelic gene sets encode identical H3 and H4 proteins
J. Mol. Biol.
Centromeric DNA from Saccharomyces cerevisiae
J. Mol. Biol.
Isolation of cloned DNA sequences containing ribosomal protein genes from Saccharomyces cerevisiae
Cell
Use of a cell cycle mutant to delineate the critical period for the control of histone mRNA in the mammalian cell cycle
Mol. Cell. Biol.
Spliced early mRNAs of simian virus 40
Cited by (138)
Replication stress inhibits synthesis of histone mRNAs in yeast by removing Spt10p and Spt21p from the histone promoters
2021, Journal of Biological ChemistryA novel role for Nhp6 proteins in histone gene regulation in Saccharomyces cerevisiae
2017, International Journal of Biochemistry and Cell BiologyWEE1 tyrosine kinase, a novel epigenetic modifier
2013, Trends in GeneticsA global requirement for the HIR complex in the assembly of chromatin
2012, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :In budding yeast, the histone genes are positively and negatively regulated during the cell cycle by a number of factors acting through cis-acting elements present in their promoter [4]. In addition to conserved upstream activation elements (UAS) in their promoter, six of the eight histone genes (HTA1-HTB1, HHT1-HHF1 and HHT2-HHF2; referred to as the HIR-dependent histone genes) contain a negative regulatory site, named the NEG or CCR region, which is in close proximity to the UAS elements [64,65]. The cell cycle regulated UAS elements are required to activate histone gene transcription at the G1/S transition through the recruitment of activators such as Spt10 and the SBF transcription factors [66,67], while the negative element is required for repression outside of S phase and in response to hydroxyurea (HU) [26,64,65] (see Fig. 3A).
The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity
2012, Journal of Biological ChemistryThe mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition
2012, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :We disrupted the HIR1 gene in a clb1Δclb2tsclb3Δclb4Δ strain and examined HTA1 and HTB1 mRNA levels in synchronized cultures at both 24 °C and 37 °C (Fig. 5A and B). As previously shown [26,29](and data not shown), deletion of HIR1, similar to removal of the negative site, resulted in a higher level of mRNA accumulation in G1, G2, and M phases, although peak levels were still achieved in early S-phase under permissive conditions (Fig. 5A and B, 24 °C). Strikingly, under nonpermissive conditions (37 °C) (Fig. 5A and B, 37 °C), HTA1 and HTB1 mRNA accumulated to the same levels as under permissive conditions (24 °C) in the first cell cycle in a clb1Δclb2tsclb3Δclb4Δhir1Δ strain.
- ★
Present address: Department of Biological Sciences, University of Warwick, Coventry, West Midlands, England.
- †
Present address: Department of Biochemistry, Oxford University, South Parks Road, Oxford, England.