Cell
ArticleBinding of antigen in the absence of histocompatibility proteins by arsonate-reactive T-cell clones
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Cited by (72)
XLck availability during thymic selection determines the recognition specificity of the T cell repertoire
2013, CellCitation Excerpt :According to the germline model, specific amino acids in the complementary determining regions (CDR) 1 and 2 of TCRα and TCRβ have been conserved during evolution because they contact MHC chains and impose MHC specificity on αβTCR recognition. Consequently, αβTCR are limited by germline imposed structural constraints to be MHC-specific and to bind only to MHC-dependent ligands, with the exception of a few exceedingly rare αβTCR that cross-reactively bind an MHC-independent ligand with very low affinity (Barnd et al., 1989; Hanada et al., 2011; Rao et al., 1984). In contrast to the germline model, the selection model of MHC restriction proposes that MHC restriction is the result of TCR-signaled thymic selection and is not an intrinsic feature of αβTCR structure (Collins and Riddle, 2008; Tikhonova et al., 2012; Van Laethem et al., 2007, 2012).
MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection
2012, Trends in ImmunologyCitation Excerpt :As a result, αβ TCR signaling in DP thymocytes is dependent on co-receptor-associated Lck. A few αβ TCRs obtained from mature T cells have been identified over the years that bind to ligands independently of MHC, although they do this with low apparent affinity [27–29]. As a result of their low binding affinity, it has been argued that their MHC-independent ligands are not their primary specificities and, therefore, such αβ TCRs do not contradict the germline concept that MHC restriction is intrinsic to αβ TCR structure.
αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities
2012, ImmunityCitation Excerpt :Based on these structural analyses, it has been proposed that germline-encoded amino acid residues in the invariant CDR2 region specifically promote MHC binding and account for the preferential binding of αβTCRs to pMHC complexes (Garcia et al., 2009; Marrack et al., 2008). Notably, the germline basis of MHC restriction is not contradicted by reports of rare αβTCRs cloned from conventional T cell populations that bind ligands independently of MHC molecules (Barnd et al., 1989; Hanada et al., 2011; Rao et al., 1984; Siliciano et al., 1985) because their MHC-independent ligand is bound with such low apparent affinity that it is likely not to be their TCR's primary recognition specificity (Garcia et al., 2009). An alternative to the germline concept is that MHC restriction is imposed by thymic selection (Collins and Riddle, 2008; Van Laethem et al., 2007).
T-cell receptor crossreactivily and autoimmune disease
2000, Advances in ImmunologyRecognition of local anesthetics by αβ<sup>+</sup> T cells
1999, Journal of Investigative DermatologyA phage display system for detection of T cell receptor-antigen interactions
1995, Molecular Immunology