Elsevier

Preventive Medicine

Volume 15, Issue 3, March 1986, Pages 292-303
Preventive Medicine

General article
Young adult cholesterol as a predictor of familial ischemic heart disease

https://doi.org/10.1016/0091-7435(86)90048-4Get rights and content

Abstract

Family history for ischemic heart disease (IHD) was quantified from 229 questionnaires returned by the parents of young adults who had their total serum cholesterol levels determined as seventh graders in 1972–1973 and again 9 years later. The participants were divided into low- or high-cholesterol groups using quintiles. There were nonsignificant trends for higher prevalence of IHD in the families of individuals, principally the male participants, with persistently high total serum cholesterol levels; an excess of IHD in families of young adults with reduced high-density lipoprotein cholesterol (HDL); and a deficit of IHD in families of high-HDL participants. There was a significant interaction in family history scores between HDL and total cholesterol, such that there was an excess of IHD prevalence in families of individuals with high total cholesterol and low HDL levels, and significantly lower IHD prevalence in families of young adults with high total cholesterol and high HDL levels. Among individuals with low total cholesterol, lower family history scores were found in those with lower HDL levels.

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      xi. Reed’s score (Reed et al., 1986): This is calculated using the formula (O-E/√E), here O is the observed number of family members with illness, with weights in proportion to the distance from proband and E is the expected number of family members with a positive history of the illness, considering the age and sex of each family member and the age and sex-specific prevalence of the illness, in the general population. Simulations by Murad et al.(Murad et al., 2007) demonstrated that Reed’s score performs better than other methods which account for observed to expected rates.

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    Partially supported by Senior Research Fellowships 1-F33-HL06509-01 (T.R.), NRSA HL07011-08 (R.P.D.), and 5-K01-AM0885-3, and by the Beaver County Heart Association.

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    Present address: Division of Epidemiology and Clinical Applications, Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, Md. 20892.

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