Clinical Immunology and Immunopathology
Regular articleMechanisms of human CD5 modulation and capping induced by murine monoclonal antibody T101
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Progress and Pitfalls of Chimeric Antigen Receptor T Cell Immunotherapy against T Cell Malignancies
2024, Transplantation and Cellular TherapyA T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies
2015, BloodCitation Excerpt :However, surface expression of CD5 was comparable in all leukemic cell lines and activated T cells (supplemental Figure 7A-B). Ligand binding induces rapid internalization of CD5 protein even without crosslinking.29,30 We assessed the kinetics of CD5 internalization in normal and malignant T cells after mixing them with CD5 CAR T cells.
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
2010, BloodCitation Excerpt :Although our preclinical data with XmAb5574 show potential promise for clinical investigation in CLL, there are potential pitfalls to be considered as this therapeutic antibody moves forward to the clinic. XmAb5574 binds to CD19 but shows concentration- and time-dependent internalization similar to other CD19 and CD5 antibodies that have been described.46,47 Although our studies in Figure 1C show continued expression of CD19 on the external portion of the CLL cells, it is possible that the internalization observed with this antibody could compromise its efficacy compared with clinically used antibodies such as alemtuzumab and rituximab that internalize less.
Antigen Loss From Antibody-Coated Red Blood Cells
2009, Transfusion Medicine ReviewsCitation Excerpt :Antigen loss has also been seen in the setting of monoclonal antibody treatment of neoplasia. This was originally termed antigenic modulation and was observed by several groups using both primary lymphocytes and cell lines.44-48 A particularly detailed analysis of antigenic modulation has been performed by Taylor et al using a therapeutic anti-CD20 antibody (ie, rituximab) and its target (ie, neoplastic or primary B cells).
Anti-T cell immunotoxins: a look at post-endocytotic receptor-mediated routing
1993, Journal of Controlled Release