Antinuclear, anticytoplasmic, and anti-Sjogren's Syndrome antigen A (SS-A/Ro) antibodies in female blood donors

doi:10.1016/0090-1229(85)90045-5

Clinical Immunology and Immunopathology

Volume 36, Issue 1, July 1985, Pages 120-128

Clinical Immunology ...

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Abstract

A study of 2500 sera from female blood donors between the ages of 20 and 50 years was undertaken to determine the frequency of antinuclear (ANA), anticytoplasmic (ACA), and antimitochondrial (AMA) antibodies. When sera were tested by immuno-fluorescence (IF) on HEp-2 cells, 15.9 and 1.1% had ANA titers greater than $120$ and $180$ , respectively. Analysis of these sera for autoantibody specificity showed: 1.5% antinucleolar, 1.0% anti-nuclear matrix, 0.2% anti-mitotic spindle apparatus, and 0.2% anti-primary biliary cirrhosis nuclear antigen. AMA titers of greater than $180$ were seen in 2.5% and AMA titers greater than $1160$ were seen in 1.0%. None of the sera had anti-double stranded DNA. Testing of an additional 2500 sera for anti-Sjogren's Syndrome antigen A (anti-SS-A/Ro) revealed a frequency of $225000$ (0.44%) with the highest frequency (0.72%) being in the 45 – 50 age group and a relatively high frequency (0.58%) in the 20 – 24 age group.

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Antinuclear, anticytoplasmic, and anti-Sjogren's Syndrome antigen A (SS-A/Ro) antibodies in female blood donors

Abstract

Adv. Immunol.

Lancet

Manual of Clinical Immunology

Clin. Exp. Immunol.

J. Rheumatol.

Amer. J. Clin. Pathol.

J. Lab. Clin. Immunol.

Ann. Rheum. Dis.

J. Rheum.

Amer. J. Clin. Pathol.